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SCOPUS Özgün Makale Scopus
Fatty Acid Composition, Antioxidant, and Enzyme Inhibition Activities of Cachrys Crassiloba (Boiss.) Meikle Fruit and Leaf Extracts
Journal of the Turkish Chemical Society Section A: Chemistry 2024 Cilt 11
Scopus Eşleşmesi Bulundu
11
Cilt
723-730
Sayfa
🔓
Açık Erişim
Scopus Yazarları: Tugsen Buyukyildirim, Yavuz Bağci, Nuraniye Eruygur, M. Raşit Bakır
Özet
The genus Cachrys L. (Apiaceae) is distributed in the Mediterranean region and contains 11 spe-cies. C. crassiloba (Boiss.) Meikle is a species that grows in Southwest and Western Anatolia. Considering the literature studies, there were not enough studies on C. crassiloba. In this study, fatty acid composition, total phenol/flavonoid contents, antioxidant and acetyl-butrylcholinesterase, tyrosinase, and α-glucosidase enzyme inhibition activities of n-hexane and ethanol extracts prepared from C. crassiloba fruits and leaves were investigated by spectrophotometric methods at different concentrations. When the results were evaluated, it was found that the hexane extract of C. crassiloba leaf (123.92 ± 4.62 GA mg/g extract) had the highest total phenol content, while the ethanol extract of C. crassiloba fruit (134.38 ± 0.98 QE mg/g extract) had the highest flavonoid content. C. crassiloba hexane and ethanol leaf extracts (IC50= 8.04 ± 1.31 µg/mL; 10.30 ± 3.15 µg/mL) showed good antioxidant activity compared to the ascorbic acid (IC50= 14.59 ± 1.96 µg/mL) in DPPH assay. C. crassiloba leaf ethanol extract (IC50= 17.38 ± 5.02 µg/mL) has the highest ABTS scavenging activity. C. crassiloba extracts have moderate cholinesterase inhibitory activity. C. crassiloba leaf ethanol extract (IC50= 196.65 ± 1.94 µg/mL) has good tyrosinase enzyme inhibition activity. C. crassiloba leaf hexane extract (36.35% ± 1.13) was found to have significant inhibitory activity against α-glucosidase. In conclusion, besides its antioxidant activity, C. crassiloba may be effective against neurodegenerative diseases and skin disorders such as hyperpigmentation and diabetes mellitus, but further phytochemical analysis studies are required.
Anahtar Kelimeler (Scopus)
Antioxidant activity Apiaceae Cachrys crassiloba Enzyme inhibition activity Fatty acid composition

Anahtar Kelimeler

Antioxidant activity Apiaceae Cachrys crassiloba Enzyme inhibition activity Fatty acid composition

Makale Bilgileri

Dergi Journal of the Turkish Chemical Society Section A: Chemistry
ISSN 2149-0120
Yıl 2024 / 5. ay
Cilt / Sayı 11
Makale Türü Özgün Makale
Hakemlik Hakemli
Endeks SCOPUS
Yayın Dili Türkçe
Kapsam Uluslararası
Toplam Yazar 4 kişi
Erişim Türü Basılı+Elektronik
Erişim Linki Makaleye Git
Alan Sağlık Bilimleri Temel Alanı Farmakognozi

YÖKSİS Yazar Kaydı

Yazar Adı BÜYÜKYILDIRIM TUĞSEN,BAĞCI YAVUZ,ERUYGUR NURANİYE,Bakır Muhammed Raşit
YÖKSİS ID 8047920