Scopus Eşleşmesi Bulundu
3
Atıf
5
Cilt
🔓
Açık Erişim
Scopus Yazarları: Astrid Marchal, Evangelos Bellos, Ryan S. Thwaites, Andrés Augusto Arias, Lisa M. Arkin, Hagit Baris Feldman, Alexandre Belot, Catherine M. Biggs, Alessandro Borghesi, Antonio Condino-Neto, Megan A. Cooper, Peter K. Gregersen, Lennart Hammarström, Tom Maniatis, France Mentré, Kelly M. Schiabor Barrett, Yu Zhang, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Saleh Zaid Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Paul Bastard, Alexandre Bolze, Yenan T. Bryceson, Jean Laurent Casanova, Aurélie Cobat, Jacques Fellay, Jose Luis Franco, Antoine Froidure, Yu Lung Lau, Trine H. Mogensen, Tomohiro Morio, David S. Perlin, Graziano Pesole, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Evangelos Andreakos, Dusan Bogunovic, Anastasiia Bondarenko, Ahmed A. Bousfiha, Petter Brodin, Manish J. Butte, Giorgio Casari, John Christodoulou, Filomeen Haerynck, David Hagin, James R. Heath, Elena W.Y. Hsieh, Eystein Husebye, Kohsuke Imai, Yuval Itan, Yun Ling, Carrie L. Lucas, Lisa F.P. Ng, Antonio Novelli, Tayfun Ozcelik, Rebeca Pérez de Diego, Jordi Perez-Tur, Elizabeth T. Cirulli, Iva Neveux, Ivana Nemes-Bokun, Laurent Abel, Alessandro Aiuti, Roger Colobran, Stefan N. Constantinescu, Clifton L. Dalgard, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Carlos Flores, Bodo Grimbacher, Rabih Halwani, Emmanuelle Jouanguy, Elżbieta Kaja, Timokratis Karamitros, Kai Kisand, Cheng Lung Ku, Davood Mansouri, László Maródi, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Luigi Notarangelo, Giuseppe Novelli, Cliona O'Farrelly, Satoshi Okada, Keisuke Okamoto, Qiang Pan-Hammarström, Jean W. Pape
Özet
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
Anahtar Kelimeler (Scopus)
association
asymptomatic infection
COVID-19
HLA
population stratification
Anahtar Kelimeler
association
asymptomatic infection
COVID-19
HLA
population stratification
Makale Bilgileri
Dergi
Human Genetics and Genomics Advances
ISSN
2666-2477
Yıl
2024
/ 7. ay
Cilt / Sayı
5
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
ESCI
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
1512 kişi
Erişim Türü
Basılı+Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı
Çocuk Enfeksiyon Hastalıkları (Çocuk Sağlığı ve Hastalıkları)
YÖKSİS Yazar Kaydı
Yazar Adı
ÖZÇELİK HASAN TAYFUN,TEMEL ŞEHİME GÜLSÜN,ALKAN GÜLSÜM,AYTEKİN GÖKHAN,BAYHAN GÜLSÜM İCLAL,ELMAS BOZDEMİR ŞEFİKA,EMİROĞLU MELİKE,ERDENİZ EMİNE HAFİZE,GAYRETLİ AYDIN ZEYNEP GÖKÇE,GÜLHAN BELGİN,HANÇERLİ TÖRÜN SELDA,HATİPOĞLU NEVİN,HEPPEKCAN DENİZ,KANIK YÜKSEK SALİHA,KARA YALÇIN,KARAHAN AYDIN,KARBUZ ADEM,KART YAŞAR KADRİYE,KASAPÇOPUR ÖZGÜR,KELEŞ SEVGİ,KENDİR DEMİRKOL YASEMİN,KIZIL CAN,KILIÇ AHMET OSMAN,METİN AKCAN ÖZGE,KARABELA ŞEMSİ NUR,ÖZKAYA PARLAKAY ASLI NUR,TÜTER ÖZ ŞADİYE KÜBRA,YAHŞİ AYSUN,YEŞİLBAŞ OSMAN,YILDIZ MEHMET,YÜKSELMİŞ UFUK
YÖKSİS ID
7945926
Hızlı Erişim
Metrikler
Scopus Atıf
3
Yazar Sayısı
1512