Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Human Genetics and Genomics Advances · Temmuz 2024
YÖKSİS Kayıtları
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Human Genetics and Genomics Advances · 2024 ESCI
DOÇENT MELİKE EMİROĞLU →
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Human Genetics and Genomics Advances · 2024 ESCI
DOÇENT GÜLSÜM ALKAN →
Makale Bilgileri
DergiHuman Genetics and Genomics Advances
Yayın TarihiTemmuz 2024
Cilt / Sayfa5
Scopus ID2-s2.0-85195515679
Erişim🔓 Açık Erişim
Özet
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
Yazarlar (100)
1
Astrid Marchal
2
Elizabeth T. Cirulli
3
Iva Neveux
4
Evangelos Bellos
ORCID: 0000-0002-3389-5715
5
Ryan S. Thwaites
6
Kelly M. Schiabor Barrett
7
Yu Zhang
8
Ivana Nemes-Bokun
9
Mariya Kalinova
10
Andrew Catchpole
11
Stuart G. Tangye
12
András N. Spaan
13
Justin B. Lack
14
Jade Ghosn
15
Charles Burdet
16
Guy Gorochov
17
Florence Tubach
18
Pierre Hausfater
19
Laurent Abel
ORCID: 0000-0001-7016-6493
20
Alessandro Aiuti
21
Saleh Zaid Al-Muhsen
22
Fahd Al-Mulla
23
Ali Amara
24
Mark S. Anderson
25
Evangelos Andreakos
26
Andrés Augusto Arias
27
Lisa M. Arkin
28
Hagit Baris Feldman
29
Paul Bastard
30
Alexandre Belot
ORCID: 0000-0003-4902-5332
31
Catherine M. Biggs
32
Dusan Bogunovic
33
Alexandre Bolze
ORCID: 0000-0001-7399-2766
34
Anastasiia Bondarenko
ORCID: 0000-0002-9737-2868
35
Alessandro Borghesi
36
Ahmed A. Bousfiha
37
Petter Brodin
38
Yenan T. Bryceson
39
Manish J. Butte
40
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
41
Giorgio Casari
42
John Christodoulou
43
Aurélie Cobat
ORCID: 0000-0001-7209-6257
44
Roger Colobran
45
Antonio Condino-Neto
ORCID: 0000-0002-1069-3117
46
Stefan N. Constantinescu
47
Megan A. Cooper
48
Clifton L. Dalgard
49
Murkesh Desai
50
Beth A. Drolet
51
Xavier Duval
52
Jamila El Baghdadi
53
Philippine Eloy
54
Sara Espinosa-Padilla
55
Jacques Fellay
56
Carlos Flores
57
Jose Luis Franco
58
Antoine Froidure
59
Peter K. Gregersen
60
Bodo Grimbacher
61
Filomeen Haerynck
ORCID: 0000-0001-9161-7361
62
David Hagin
63
Rabih Halwani
64
Lennart Hammarström
65
James R. Heath
66
Elena W.Y. Hsieh
67
Eystein Husebye
68
Kohsuke Imai
69
Yuval Itan
70
Emmanuelle Jouanguy
ORCID: 0000-0002-7358-9157
71
Elżbieta Kaja
72
Timokratis Karamitros
73
Kai Kisand
74
Cheng Lung Ku
75
Yu Lung Lau
ORCID: 0000-0002-4780-0289
76
Yun Ling
77
Carrie L. Lucas
78
Tom Maniatis
79
Davood Mansouri
80
László Maródi
81
France Mentré
82
Isabelle Meyts
83
Joshua D. Milner
84
Kristina Mironska
85
Trine H. Mogensen
86
Tomohiro Morio
87
Lisa F.P. Ng
88
Luigi Notarangelo
ORCID: 0000-0002-8335-0262
89
Antonio Novelli
90
Giuseppe Novelli
91
Cliona O'Farrelly
92
Satoshi Okada
93
Keisuke Okamoto
94
Tayfun Ozcelik
ORCID: 0000-0001-5937-1082
95
Qiang Pan-Hammarström
96
Jean W. Pape
97
Rebeca Pérez de Diego
ORCID: 0000-0001-8426-8765
98
Jordi Perez-Tur
99
David S. Perlin
100
Graziano Pesole
Anahtar Kelimeler
association
asymptomatic infection
COVID-19
HLA
population stratification
Kurumlar
Centre Hospitalier Universitaire Vaudois
Lausanne Switzerland
École Polytechnique Fédérale de Lausanne
Lausanne Switzerland
Garvan Institute of Medical Research
Sydney Australia
Helix
San Mateo United States
Hôpital Bichat-Claude-Bernard AP-HP
Paris France
Hôpital Necker Enfants Malades
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Howard Hughes Medical Institute
Chevy Chase United States
hVIVO Services Limited
London United Kingdom
Imperial College London
London United Kingdom
Leidos Inc.
Reston United States
l'Institut des Maladies Génétiques Imagine
Paris France
National Heart and Lung Institute
London United Kingdom
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
Rockefeller University
New York United States
SIB Swiss Institute of Bioinformatics
Lausanne Switzerland
Sorbonne Université
Paris France
Uniformed Services University of the Health Sciences
Bethesda United States
Université Paris Cité
Paris France
University Medical Center Utrecht
Utrecht Netherlands
University of Nevada, Reno School of Medicine
Reno United States
UNSW Sydney
Sydney Australia
Metrikler
3
Atıf
100
Yazar
5
Anahtar Kelime