Scopus Eşleşmesi Bulundu
16
Atıf
221
Cilt
🔓
Açık Erişim
Scopus Yazarları: Adrian Gervais, Maki Taniguchi, Miyuki Tsumura, Maya Husain, Hassan Abolhassani, Sabina Sahanic, Ivan Tancevski, Yoko Nukui, Seiichi Hayakawa, Paul Bastard, Alexandre Belot, Tomohiro Morio, Junko Tanaka, Etienne Javouhey, Liisa Saare, Karita Särekannu, Lucy Bizien, Sevgi Keles, Qiang Pan-Hammarström, Camille Soudee, Vincent Arseguel, Athanasios Michos, Elizabeth Barbara Tatsi, Filippos Filippatos, Jesus Troya, Tom Le Voyer, Quentin Philippot, Jérémie Rosain, Takaki Asano, Marina Garcia-Prat, Alba Parra-Martínez, Mélanie Migaud, Francesca Conti, Jacques G. Rivière, Filomeen Haerynck, Tayfun Ozcelik, Yacine Tandjaoui-Lambiotte, Simon Escoda, Lennart Hammarström, Gloria Ahlijah, Anthony Abi Haidar, Isabelle Meyts, Lucie Roussel, Sisse Rye Ostrowski, Laire Schidlowski, Pierre Quartier, Bertrand Boisson, Vivien Béziat, Alessandro Borghesi, Andrea Pession, Laurent Abel, Luis I. Gonzalez-Granado, Anne Puel, Gulsum Alkan, Riccardo Castagnoli, Sefika Elmas Bozdemir, Belgin Gulhan, Sotirija Duvlis, George P. Chrousos, Imran Tipu, Evangelos Andreakos, Carlos Rodriguez-Gallego, Roger Colobran, Vallo Tillmann, Bénédicte Neven, Sophie Trouillet-Assant, Satoshi Okada, Jean Laurent Casanova, Sergio Aguilera-Albesa, Nevin Hatipoglu, Saliha Kanik-Yuksek, Agusti Rodriguez-Palmero, Antonio Condino-Neto, Nathalie Cheikh, Aurora Pujol, Romain Lévy, Donald C. Vinh, Shen Ying Zhang, Nico Marr, Alexios Fotios A. Mentis, Trine H.mogensen, Pere Soler-Palacin, Petter Brodin, Qian Zhang, Federico Martinón-Torres, Antonio Salas, Alberto Gómez-Carballa, Aurélie Cobat, Cyril Cyrus, Melike Emiroglu, Emine Hafize Erdeniz, Gulsum Iclal Bayhan, Petr Jabandziev, Carolina Prando, Ahmed A. Bousfiha, Jalila El Bakkouri, Pärt Peterson, Emmanuelle Jouanguy, Kai Kisand, Suzan A. AlKhater
Özet
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.
Anahtar Kelimeler (Scopus)
Innate immunity and inflammation
COVID-19
Immunodeficiency
Infectious disease and host defense
Anahtar Kelimeler
Innate immunity and inflammation
COVID-19
Immunodeficiency
Infectious disease and host defense
Makale Bilgileri
Dergi
Journal of Experimental Medicine
ISSN
0022-1007
Yıl
2024
/ 1. ay
Cilt / Sayı
221
/ 2
Sayfalar
1 – 19
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q1
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
300 kişi
Erişim Türü
Basılı+Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı
Çocuk Enfeksiyon Hastalıkları (Çocuk Sağlığı ve Hastalıkları)
YÖKSİS Yazar Kaydı
Yazar Adı
ÖZÇELİK HASAN TAYFUN,KELEŞ SEVGİ,ALKAN GÜLSÜM,ELMAS BOZDEMİR ŞEFİKA,EMİROĞLU MELİKE,GÜLHAN BELGİN,ERDENİZ EMİNE HAFİZE,HATİPOĞLU NEVİN,BAYHAN GÜLSÜM İCLAL,KANIK YÜKSEK SALİHA,KARBUZ ADEM,TÜTER ÖZ ŞADİYE KÜBRA,METİN AKCAN ÖZGE,KILIÇ AHMET OSMAN,ÖZKAYA PARLAKAY ASLI NUR,YAHŞİ AYSUN
YÖKSİS ID
7945871
Hızlı Erişim
Metrikler
Scopus Atıf
16
JCR Quartile
Q1
Yazar Sayısı
300