Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Journal of Experimental Medicine · Ocak 2024
YÖKSİS Kayıtları
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Journal of Experimental Medicine · 2024 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Journal of Experimental Medicine · 2024 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiJournal of Experimental Medicine
Yayın TarihiOcak 2024
Cilt / Sayfa221
Scopus ID2-s2.0-85181628485
Erişim🔓 Açık Erişim
Özet
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.
Yazarlar (100)
1
Paul Bastard
2
Adrian Gervais
3
Maki Taniguchi
4
Liisa Saare
5
Karita Särekannu
6
Tom Le Voyer
7
Quentin Philippot
8
Jérémie Rosain
9
Lucy Bizien
10
Takaki Asano
11
Marina Garcia-Prat
12
Alba Parra-Martínez
13
Mélanie Migaud
14
Miyuki Tsumura
15
Francesca Conti
16
Alexandre Belot
ORCID: 0000-0003-4902-5332
17
Jacques G. Rivière
18
Tomohiro Morio
19
Junko Tanaka
20
Etienne Javouhey
21
Filomeen Haerynck
ORCID: 0000-0001-9161-7361
22
Sotirija Duvlis
23
Tayfun Ozcelik
ORCID: 0000-0001-5937-1082
24
Sevgi Keles
25
Yacine Tandjaoui-Lambiotte
26
Simon Escoda
27
Maya Husain
28
Qiang Pan-Hammarström
29
Lennart Hammarström
30
Gloria Ahlijah
31
Anthony Abi Haidar
32
Camille Soudee
33
Vincent Arseguel
34
Hassan Abolhassani
35
Sabina Sahanic
36
Ivan Tancevski
37
Yoko Nukui
38
Seiichi Hayakawa
39
George P. Chrousos
40
Athanasios Michos
41
Elizabeth Barbara Tatsi
42
Filippos Filippatos
43
Agusti Rodriguez-Palmero
ORCID: 0000-0002-4141-5515
44
Jesus Troya
45
Imran Tipu
46
Isabelle Meyts
47
Lucie Roussel
48
Sisse Rye Ostrowski
49
Laire Schidlowski
50
Carolina Prando
51
Antonio Condino-Neto
ORCID: 0000-0002-1069-3117
52
Nathalie Cheikh
53
Ahmed A. Bousfiha
54
Jalila El Bakkouri
55
Pärt Peterson
56
Aurora Pujol
ORCID: 0000-0002-9606-0600
57
Romain Lévy
58
Pierre Quartier
59
Donald C. Vinh
60
Bertrand Boisson
61
Vivien Béziat
62
Shen Ying Zhang
ORCID: 0000-0002-9449-3672
63
Alessandro Borghesi
64
Andrea Pession
65
Evangelos Andreakos
66
Nico Marr
67
Alexios Fotios A. Mentis
68
Trine H.mogensen
69
Carlos Rodriguez-Gallego
70
Pere Soler-Palacin
71
Roger Colobran
72
Vallo Tillmann
73
Bénédicte Neven
74
Sophie Trouillet-Assant
75
Petter Brodin
76
Laurent Abel
ORCID: 0000-0001-7016-6493
77
Emmanuelle Jouanguy
ORCID: 0000-0002-7358-9157
78
Qian Zhang
79
Federico Martinón-Torres
80
Antonio Salas
81
Alberto Gómez-Carballa
82
Luis I. Gonzalez-Granado
83
Kai Kisand
84
Satoshi Okada
85
Anne Puel
86
Aurélie Cobat
ORCID: 0000-0001-7209-6257
87
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
88
Sergio Aguilera-Albesa
89
Suzan A. AlKhater
ORCID: 0000-0001-7315-6581
90
Gulsum Alkan
ORCID: 0000-0003-3384-769X
91
Riccardo Castagnoli
92
Cyril Cyrus
ORCID: 0000-0001-7333-6486
93
Sefika Elmas Bozdemir
ORCID: 0000-0003-1058-0320
94
Melike Emiroglu
ORCID: 0000-0003-1307-0246
95
Belgin Gulhan
ORCID: 0000-0003-0839-1301
96
Emine Hafize Erdeniz
97
Nevin Hatipoglu
98
Gulsum Iclal Bayhan
ORCID: 0000-0002-1423-4348
99
Petr Jabandziev
100
Saliha Kanik-Yuksek
ORCID: 0000-0002-2538-2872
Anahtar Kelimeler
COVID-19
Immunodeficiency
Infectious disease and host defense
Innate immunity and inflammation
Kurumlar
Aarhus Universitet
Aarhus Denmark
Aarhus Universitetshospital
Aarhus Denmark
Academy of Athens
Athens Greece
Alma Mater Studiorum Università di Bologna
Bologna Italy
Ankara Yildirim Beyazit University
Ankara Turkey
Bilkent Üniversitesi
Ankara Turkey
Bursa City Hospital
Bursa Türkiye
Centre Hospitalier Universitaire de Besançon
Besancon France
Centre Hospitalier Universitaire Ibn Rochd
Casablanca Morocco
Centre Universitaire de Santé McGill
Montreal Canada
Centro de Investigación Biomédica en Red de Enfermedades Raras
Madrid Spain
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Madrid Spain
Children’s Hospital
Ankara Turkey
CHU de Lyon
Lyon France
Departement Microbiologie, Immunologie en Transplantatie
Leuven Belgium
École Normale Supérieure de Lyon
Lyon France
Faculdades Pequeno Príncipe
Curitiba Brazil
Facultade de Veterinaria
Lugo Spain
Faculty of Medical Sciences, Goce Delcev University
Stip North Macedonia
Fakultni Nemocnice Brno
Brno Czech Republic
Fondazione IRCCS Policlinico San Matteo
Pavia Italy
Graduate School of Medical and Dental Sciences
Tokyo Japan
Hiroshima University Graduate School of Biomedical and Health Sciences
Hiroshima Japan
Hôpital Necker Enfants Malades
Paris France
Hospital Clínico Universitario de Santiago
Santiago de Compostela Spain
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Hospital Duran i Reynals
Barcelona Spain
Hospital Universitari de Bellvitge
Barcelona Spain
Hospital Universitari Germans Trias i Pujol
Badalona Spain
Hospital Universitario 12 de Octubre
Madrid Spain
Hospital Universitario Infanta Leonor
Madrid Spain
Howard Hughes Medical Institute
Chevy Chase United States
Hypoxie & Poumon (H&P)
Bobigny France
Imam Abdulrahman Bin Faisal University
Dammam Saudi Arabia
Imperial College London
London United Kingdom
Infection, Anti-Microbien, Modélisation, Évolution
Paris France
Institució Catalana de Recerca i Estudis Avançats
Barcelona Spain
Institut d'Investigació Biomedica de Bellvitge
Hospitalet de Llobregat Spain
Institute of Public Health of the Republic of North Macedonia
Skopje North Macedonia
Institute of Science Tokyo
Tokyo Japan
Institute of Science Tokyo Hospital
Tokyo Japan
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna Italy
Karolinska Institutet
Stockholm Sweden
KU Leuven
Leuven Belgium
KU Leuven– University Hospital Leuven
Leuven Belgium
L'Institut de Recherche du Centre Universitaire de Santé McGill
Montreal Canada
Medizinische Universitat Innsbruck
Innsbruck Austria
National and Kapodistrian University of Athens
Athens Greece
National Reference Center for Rheumatic
Lyon France
Navarra Health Service Hospital
Pamplona Spain
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Paris Cité University
Paris France
Research Center for Immunodeficiencies
Tehran Iran
Rigshospitalet
Copenhagen Denmark
Rockefeller University
New York United States
Saint-Denis University Hospital
Saint-Denis France
Selçuk Tip Fakültesi
Konya Turkey
Sidra Medicine
Doha Qatar
Tartu Ülikool
Tartu Estonia
Universidad de Las Palmas de Gran Canaria
Las Palmas de Gran Canaria Spain
Universidade de Santiago de Compostela
Santiago de Compostela Spain
Universidade de São Paulo
Sao Paulo Brazil
Universidad Fernando Pessoa Canarias
Santa Maria de Guia de Gran Canaria Spain
Università degli Studi di Pavia
Pavia Italy
Universitair Ziekenhuis Gent
Ghent Belgium
Université de Lyon
Lyon France
Université Paris Cité
Paris France
University of Health Sciences
Istanbul Turkey
University of Management and Technology Lahore
Lahore Pakistan
Vall d'Hebron Institut de Recerca
Barcelona Spain
Metrikler
16
Atıf
100
Yazar
4
Anahtar Kelime