This work aims to evaluate the effectiveness of inter-ply/intra-tow hybridization in 3D woven composites to achieve an ameliorated impact and flexural performance. In this regard, inter-ply/intra-tow hybrid epoxy composites with Kevlar, E-glass, and ultra-high-molecular-weight polyethylene (UHMWPE) reinforced 3D fabrics are manufactured using the vacuum infusion method. To scrutinize the static and dynamic responses, the produced composites are subjected to flexural and low-velocity impact (50, 100, and 150 J) tests. The findings show that inter-ply hybrid composites exhibit more improved impact and flexural performance than their intra-tow hybrid counterparts. While the elastic moduli and strength values of weft-directional hybrid composites increase, on the contrary, warp-directional counterparts do not display an enhancement in flexural performance. Scanning electron microscopy (SEM) examinations and acoustic emission analysis are conducted together on the bending specimens to understand failure mechanisms leading to observed mechanical responses.