This study aimed to determine the pharmacokinetics and pharmacokinetic interaction between oxfendazole (7.5 mg/kg) and oxyclozanide (15 mg/kg) tablet formulation administered either alone or co-administered to goats orally. The study was carried out to the cross-over design into three periods, with a washout period of 21 days among administrations, on six healthy Alpine goats 1 year of age. The plasma concentrations of oxfendazole, oxfendazole metabolites fenbendazole and fenbendazole sulfone, and oxyclozanide were determined using HPLC-UV, and data were analyzed by the non-compartmental method. The plasma concentrations of oxfendazole were similar in both oxfendazole and combined groups. When oxfendazole was administered alone or in combination with oxyclozanide, the compounds recovered in plasma were oxfendazole, fenbendazole sulfone, and fenbendazole. Oxyclozanide did not change the plasma disposition of oxfendazole. In the oxyclozanide group, t1/2λz, Cmax, Tmax, and AUC0-∞ were estimated at 15.3 h, 11.6 µg/mL, 24 h, and 554 h × µg/mL, respectively. In the oxyclozanide plus oxfendazole treatment group, AUC0-∞ (1111 h×µg/mL), and Cmax (23.9 µg/mL) values were increased. In goats, the anthelmintic efficacy of oxfendazole and oxyclozanide should be determined by taking into account their pharmacokinetic data.