Scopus Eşleşmesi Bulundu
413
Atıf
6
Cilt
🔓
Açık Erişim
Scopus Yazarları: H. Heinrich Hoffmann, Shohei Eto, Karita Särekannu, Paul Bastard, Tom Le Voyer, Eleftherios Michailidis, Rui Yang, Liis Haljasmägi, Yacine Tandjaoui-Lambiotte, Charles Edouard Luyt, Julien Poissy, Pascal Morel, Alexandre Belot, Jacques G. Rivière, Jean Christophe Lagier, Tomohiro Morio, Junko Tanaka, Pierre Louis Tharaux, Damien Sene, Luisa Imberti, Ottavia M. Delmonte, Andrew L. Snow, Steven M. Holland, Lazaro Lorenzo, Filomeen Haerynck, Robert Nussbaum, Sevgi Keles, Christine N. Metz, Adrian Gervais, Jérémie Rosain, Quentin Philippot, Lucy Bizien, Julia Maslovskaja, Blanca Amador-Borrero, Jesus Troya, Kahina Saker, Pierre Garçon, Lindsey B. Rosen, Juan Manuel Anaya, Paolo Bonfanti, Marcela Moncada-Velez, Soraya Boucherit, Boubacar Coulibaly, Qiang Pan-Hammarström, Alessandro Aiuti, Lucila A. Barreiros, Elena Dominguez-Garrido, Diederik van de Beek, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Jeremy Manry, Marina Garcia-Prat, Alba Parra-Martínez, Mélanie Migaud, Nicolas De Prost, Alexandre Gaudet, Pascale Richard, Fabrice Cognasse, Sophie Trouillet-Assant, Elana Shaw, Alain Stepanian, Arnaud Fekkar, Jose Luis Franco, Jordi Solé-Violán, Dany Anglicheau, Ahmed A. Bousfiha, Giorgio Casari, Fabio Ciceri, Mateus Vidigal, Mayana Zatz, Sabina Sahanic, Yurii Stepanovskyy, Yoko Nukui, Stuart G. Tangye, Stéphanie Gentile, David Dalmau, Bruno Megarbane, Vasiliki Triantafyllia, James R. Heath, Andrea Biondi, Riccardo Castagnoli, Yu Zhang, Catherine M. Biggs, Andrés Augusto Arias, Anna M. Planas, Sotirija Duvlis, Tayfun Ozcelik, Jalila El Bakkouri, Carolina Ramirez-Santana, Stéphane Paul, Lennart Hammarström, Annabelle Dupont, Alina Kurolap, Vito Lampasona, Ivan Tancevski, Oksana Boyarchuk, Miyuki Tsumura, Loreto Vidaur, Sonia Burrel
Özet
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.
Makale Bilgileri
Dergi
Science Immunology
ISSN
2470-9468
Yıl
2021
/ 8. ay
Cilt / Sayı
6
/ 62
Sayfalar
4340 – 4340
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q1
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
1122 kişi
Erişim Türü
Basılı+Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı
Çocuk Enfeksiyon Hastalıkları (Çocuk Sağlığı ve Hastalıkları)
YÖKSİS Yazar Kaydı
Yazar Adı
KELEŞ SEVGİ, ÖZÇELİK HASAN TAYFUN, AKYÜZ ÖZKAN ESRA, ALKAN GÜLSÜM, AYTEKİN GÖKHAN, BAYHAN GÜLSÜM İCLAL, ÇELİK JALE BENGİ, COŞKUNER TANER, EMİROĞLU MELİKE, ERDENİZ EMİNE HAFİZE, EROL AYTEKİN SELMA, GAYRETLİ AYDIN ZEYNEP GÖKÇE, GÜLHAN BELGİN, HANÇERLİ TÖRÜN SELDA, HATİPOĞLU NEVİN, KANIK YÜKSEK SALİHA, KARA YALÇIN, KARAHAN AYDIN, KARBUZ ADEM, YAŞAR KART KADRİYE, KASAPÇOPUR ÖZGÜR, KENDİR DEMİRKOL YASEMİN, KIZIL CAN, KILIÇ AHMET OSMAN, METİN AKCAN ÖZGE, ÖZKAYA PARLAKAY ASLINUR, ŞENOĞLU SEVTAP, SÖZERİ BETÜL, TÜTER ÖZ ŞADİYE KÜBRA, UZUNHAN YURDAGÜL, YAHŞİ AYSUN, YEŞİLBAŞ OSMAN, YILDIZ MEHMET, YÜKSELMİŞ UFUK
YÖKSİS ID
7271093
Hızlı Erişim
Metrikler
Scopus Atıf
413
JCR Quartile
Q1
Yazar Sayısı
1122