Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Science Immunology · Ağustos 2021
YÖKSİS Kayıtları
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Science Immunology · 2021 SCI-Expanded
PROFESÖR JALE BENGİ ÇELİK →
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Science Immunology · 2021 SCI-Expanded
PROFESÖR JALE BENGİ ÇELİK →
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Science Immunology · 2021 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Science Immunology · 2021 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Makale Bilgileri
DergiScience Immunology
Yayın TarihiAğustos 2021
Cilt / Sayfa6
Scopus ID2-s2.0-85113517428
Erişim🔓 Açık Erişim
Özet
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.
Yazarlar (100)
1
Paul Bastard
2
Adrian Gervais
3
Tom Le Voyer
ORCID: 0000-0002-7253-3135
4
Jérémie Rosain
5
Quentin Philippot
6
Jeremy Manry
7
Eleftherios Michailidis
8
H. Heinrich Hoffmann
9
Shohei Eto
10
Marina Garcia-Prat
11
Lucy Bizien
12
Alba Parra-Martínez
13
Rui Yang
14
Liis Haljasmägi
15
Mélanie Migaud
16
Karita Särekannu
17
Julia Maslovskaja
18
Nicolas De Prost
19
Yacine Tandjaoui-Lambiotte
20
Charles Edouard Luyt
ORCID: 0000-0001-7424-2705
21
Blanca Amador-Borrero
22
Alexandre Gaudet
23
Julien Poissy
24
Pascal Morel
25
Pascale Richard
26
Fabrice Cognasse
27
Jesus Troya
28
Sophie Trouillet-Assant
29
Alexandre Belot
ORCID: 0000-0003-4902-5332
30
Kahina Saker
31
Pierre Garçon
32
Jacques G. Rivière
33
Jean Christophe Lagier
34
Stéphanie Gentile
35
Lindsey B. Rosen
36
Elana Shaw
37
Tomohiro Morio
38
Junko Tanaka
39
David Dalmau
40
Pierre Louis Tharaux
41
Damien Sene
42
Alain Stepanian
43
Bruno Megarbane
44
Vasiliki Triantafyllia
45
Arnaud Fekkar
46
James R. Heath
47
Jose Luis Franco
48
Juan Manuel Anaya
49
Jordi Solé-Violán
50
Luisa Imberti
51
Andrea Biondi
52
Paolo Bonfanti
53
Riccardo Castagnoli
54
Ottavia M. Delmonte
55
Yu Zhang
56
Andrew L. Snow
57
Steven M. Holland
58
Catherine M. Biggs
59
Marcela Moncada-Velez
60
Andrés Augusto Arias
61
Lazaro Lorenzo
62
Soraya Boucherit
ORCID: 0000-0002-8819-7594
63
Boubacar Coulibaly
64
Dany Anglicheau
65
Anna M. Planas
66
Filomeen Haerynck
ORCID: 0000-0001-9161-7361
67
Sotirija Duvlis
68
Robert Nussbaum
69
Tayfun Ozcelik
ORCID: 0000-0001-5937-1082
70
Sevgi Keles
71
Ahmed A. Bousfiha
72
Jalila El Bakkouri
73
Carolina Ramirez-Santana
74
Stéphane Paul
75
Qiang Pan-Hammarström
76
Lennart Hammarström
77
Annabelle Dupont
78
Alina Kurolap
79
Christine N. Metz
80
Alessandro Aiuti
81
Giorgio Casari
82
Vito Lampasona
83
Fabio Ciceri
84
Lucila A. Barreiros
85
Elena Dominguez-Garrido
86
Mateus Vidigal
87
Mayana Zatz
88
Diederik van de Beek
89
Sabina Sahanic
90
Ivan Tancevski
91
Yurii Stepanovskyy
92
Oksana Boyarchuk
93
Yoko Nukui
94
Miyuki Tsumura
95
Loreto Vidaur
96
Stuart G. Tangye
97
Sonia Burrel
98
Darragh Duffy
99
Lluis Quintana-Murci
100
Adam Klocperk
Kurumlar
Academy of Athens
Athens Greece
Aix Marseille Université
Marseille France
Amsterdam Neuroscience
Amsterdam Netherlands
AP-HM Assistance Publique - Hôpitaux de Marseille
Marseille France
AP-HP Assistance Publique - Hopitaux de Paris
Paris France
Bilkent Üniversitesi
Ankara Turkey
Center for Infection and Immunity of Lille (CIIL)
Lille France
Centre Hospitalier Lyon-Sud
Lyon France
Centre Hospitalier Universitaire de Saint Etienne
Saint-Etienne France
Centro de Investigación Biomédica de La Rioja (CIBIR)
Logrono Spain
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Madrid Spain
Charles University
Prague Czech Republic
CHU Averroes
Casablanca Morocco
CHU de Lyon
Lyon France
CHU Lille
Lille France
CNRS Centre National de la Recherche Scientifique
Paris France
Collège de France
Paris France
CSIC - Instituto de Investigaciones Biomedicas de Barcelona (IIBB)
Barcelona Spain
École Normale Supérieure de Lyon
Lyon France
Etablissement Français du Sang
Saint-Denis-la-Plaine France
Faculté de Santé
Creteil France
Faculty of Medical Sciences, Goce Delcev University
Stip North Macedonia
Fakultní Nemocnice v Motole
Prague Czech Republic
Fundació Docència I Recerca Mutua Terrassa
Barcelona Spain
Garvan Institute of Medical Research
Sydney Australia
Graduate School of Medical and Dental Sciences
Tokyo Japan
Grand Hôpital de l'Est Francilien
Jossigny France
Hassan II University of Casablanca
Casablanca Morocco
Hiroshima University Graduate School of Biomedical and Health Sciences
Hiroshima Japan
Hopital Avicenne
Bobigny France
Hôpital Lariboisiere AP-HP
Paris France
Hôpital Necker Enfants Malades
Paris France
Hôpital Tenon
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Hospital Universitari MútuaTerrassa
Terrassa Italy
Hospital Universitario Infanta Leonor
Madrid Spain
I. Horbachevsky Ternopil National Medical University
Ternopil Ukraine
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
Barcelona Spain
Institute for System Biology
Seattle United States
Institute for Systems Biology
Seattle United States
Institute of Public Health of the Republic of North Macedonia
Skopje North Macedonia
Institute of Science Tokyo
Tokyo Japan
Institute of Science Tokyo Hospital
Tokyo Japan
Institut Necker-Enfants Malades (INEM)
Paris France
Instituto de Salud Carlos III
Madrid Spain
Institut Pasteur de Lille
Lille France
Institut Pasteur, Paris
Paris France
IRCCS Ospedale San Raffaele
Milan Italy
Karolinska Institutet
Stockholm Sweden
Medizinische Universitat Innsbruck
Innsbruck Austria
MEPHI - Microbes, Evolution, Phylogénie et Infections
Marseille France
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
National Referee Centre for Rheumatic
Lyon France
Necmettin Erbakan Üniversitesi
Meram Turkey
Northwell Health System
New York United States
Osakidetza, Donostia University Hospital
Donostia-San Sebastian Spain
PARCC - Paris-Centre de Recherche Cardiovasculaire
Paris France
Rioja Salud
Spain
Rockefeller University
New York United States
San Raffaele Telethon Institute for Gene Therapy
Milan Italy
Santé Publique et Maladies Chroniques : Qualité de Vie Concepts, Usages et Limites, Déterminants
Marseille France
Shupyk National Healthcare University of Ukraine
Kyiv Ukraine
Spedali Civili Di Brescia
Brescia Italy
Tartu Ülikool
Tartu Estonia
Tel Aviv University
Tel Aviv-Yafo Israel
The University of British Columbia
Vancouver Canada
Uniformed Services University of the Health Sciences
Bethesda United States
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF)
Villeneuve-d'Ascq France
Unité de Recherche sur les Maladies Cardiovasculaires, le Métabolisme et la Nutrition
Paris France
Universidad de Antioquia
Medellin Colombia
Universidad del Rosario
Bogota Colombia
Universidade de São Paulo
Sao Paulo Brazil
Università degli Studi di Milano-Bicocca
Milan Italy
Università degli Studi di Pavia
Pavia Italy
Universitair Ziekenhuis Gent
Ghent Belgium
Université de Franche-Comté
Besancon France
Université de Lille
Lille France
Université de Lyon
Lyon France
Université Jean Monnet Saint Etienne
Saint-Etienne France
Université Paris Cité
Paris France
University of California, San Francisco
San Francisco United States
UNSW Medicine
Kensington Australia
UNSW Sydney
Sydney Australia
Vall d'Hebron Institut de Recerca
Barcelona Spain
Vrije Universiteit Amsterdam
Amsterdam Netherlands
Metrikler
413
Atıf
100
Yazar