Scopus Eşleşmesi Bulundu
249
Atıf
603
Cilt
587-598
Sayfa
🔓
Açık Erişim
Scopus Yazarları: Adem Karbuz, Ahmad Abou Tayoun, Anna Lena Neehus, Antoine Froidure, Aslinur Ozkaya Parlakay, Aysun Yahsi, Benedetta Bigio, Carlos Flores, Daniela Matuozzo, David S. Perlin, Davood Mansouri, Elena W.Y. Hsieh, Estelle Talouarn, Eugenia Quiros-Roldan, Filomeen Haerynck, Jacques Fellay, Jose Luis Franco, Kadriye Kart Yasar, László Maródi, Lluis Quintana-Murci, Luis Felipe Reyes, Luisa Imberti, Qian Zhang, Alexandre Belot, Anna Sediva, Anna Shcherbina, Anne Puel, Carolina Prando, Charles Edouard Luyt, Donald C. Vinh, Emmanuelle Jouanguy, Giorgio Casari, Gokhan Aytekin, Gulsum Alkan, Hagit Baris Feldman, Horst von Bernuth, Ingrid G. Bustos, Isabelle Migeotte, Jacinta Bustamante, Jamila El Baghdadi, Jean Laurent Casanova, Jeremy Manry, John Christodoulou, Juan Li, Juan Manuel Anaya, Keisuke Okamoto, Kristina Mironska, Lisa F.P. Ng, Paul Bastard, Adrian Gervais, Alexandre Bolze, Alexandre Gaudet, Zhiyong Liu, Andrés Augusto Arias, Antonio Novelli, Aurora Pujol, Evangelos Andreakos, Fahad M. Alsohime, Kai Kisand, Khalil Chaïbi, Laurent Renia, Lennart Hammarström, Luigi Notarangelo, Luis M. Allende, Alessandro Aiuti, Anastasiia Bondarenko, András N. Spaan, Andrea Guennoun, Anna M. Planas, Belgin Gulhan, Bertrand Boisson, Beth A. Drolet, Carlos Andres Arango Franco, Carlos Rodriguez-Gallego, Catherine M. Biggs, Clifton L. Dalgard, Cliona O’Farrelly, David Dalmau, Diederik van de Beek, Elena Dominguez-Garrido, Emine Hafize Erdeniz, Esra Sevketoglu, Eystein Husebye, Giuseppe Novelli, Guillaume Morelle, Gulsum Iclal Bayhan, Helen C. Su, Igor Resnick, Isabelle Meyts, Ivan Tancevski, Javier Martinez-Picado, Jérémie Rosain, Jie Chen, Jonathan Bohlen, Julian Rojas, Junqiang Ye, K. M.Furkan Uddin, Laurent Abel, Lazaro Lorenzo, Lucia Victoria Erazo
Özet
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases. The ensuing risk of death (approximately 1% across age and gender) doubles every five years from childhood onwards and is around 1.5 times greater in men than in women. Here we review the molecular and cellular determinants of critical COVID-19 pneumonia. Inborn errors of type I interferons (IFNs), including autosomal TLR3 and X-chromosome-linked TLR7 deficiencies, are found in around 1–5% of patients with critical pneumonia under 60 years old, and a lower proportion in older patients. Pre-existing auto-antibodies neutralizing IFNα, IFNβ and/or IFNω, which are more common in men than in women, are found in approximately 15–20% of patients with critical pneumonia over 70 years old, and a lower proportion in younger patients. Thus, at least 15% of cases of critical COVID-19 pneumonia can be explained. The TLR3- and TLR7-dependent production of type I IFNs by respiratory epithelial cells and plasmacytoid dendritic cells, respectively, is essential for host defence against SARS-CoV-2. In ways that can depend on age and sex, insufficient type I IFN immunity in the respiratory tract during the first few days of infection may account for the spread of the virus, leading to pulmonary and systemic inflammation.
Makale Bilgileri
Dergi
Nature
ISSN
0028-0836
Yıl
2022
/ 3. ay
Cilt / Sayı
603
/ 7902
Sayfalar
587 – 598
Makale Türü
Derleme Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q1
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
162 kişi
Erişim Türü
Basılı+Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı
Çocuk Enfeksiyon Hastalıkları
YÖKSİS Yazar Kaydı
Yazar Adı
KARBUZ ADEM, ÖZKAYA PARLAKAY ASLINUR, YAHŞİ AYSUN, GÜLHAN BELGİN, ERDENİZ EMİNE HAFİZE, ŞEVKETOĞLU ESRA, AYTEKİN GÖKHAN, ALKAN GÜLSÜM, BAYHAN GÜLSÜM İCLAL, KART YAŞAR KADRİYE, EMİROĞLU MELİKE, HATİPOĞLU NEVİN, AKÇAY NİHAL, METİN AKCAN ÖZGE, TÜTER ÖZ ŞADİYE KÜBRA, KANIK YÜKSEK SALİHA, EROL AYTEKİN SELMA, ELMAS BOZDEMİR ŞEFİKA, KARABELA ŞEMSİ NUR, KELEŞ SEVGİ, ŞENOĞLU SEVTAP, ÖZÇELİK HASAN TAYFUN
YÖKSİS ID
6789353
Hızlı Erişim
Metrikler
Scopus Atıf
249
JCR Quartile
Q1
Yazar Sayısı
162