Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Human genetic and immunological determinants of critical COVID-19 pneumonia
Nature · Mart 2022
YÖKSİS Kayıtları
Human genetic and immunological determinants of critical COVID-19 pneumonia
Nature · 2022 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Human genetic and immunological determinants of critical COVID-19 pneumonia
Nature · 2022 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiNature
Yayın TarihiMart 2022
Cilt / Sayfa603 · 587-598
Scopus ID2-s2.0-85124267100
Erişim🔓 Açık Erişim
Özet
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases. The ensuing risk of death (approximately 1% across age and gender) doubles every five years from childhood onwards and is around 1.5 times greater in men than in women. Here we review the molecular and cellular determinants of critical COVID-19 pneumonia. Inborn errors of type I interferons (IFNs), including autosomal TLR3 and X-chromosome-linked TLR7 deficiencies, are found in around 1–5% of patients with critical pneumonia under 60 years old, and a lower proportion in older patients. Pre-existing auto-antibodies neutralizing IFNα, IFNβ and/or IFNω, which are more common in men than in women, are found in approximately 15–20% of patients with critical pneumonia over 70 years old, and a lower proportion in younger patients. Thus, at least 15% of cases of critical COVID-19 pneumonia can be explained. The TLR3- and TLR7-dependent production of type I IFNs by respiratory epithelial cells and plasmacytoid dendritic cells, respectively, is essential for host defence against SARS-CoV-2. In ways that can depend on age and sex, insufficient type I IFN immunity in the respiratory tract during the first few days of infection may account for the spread of the virus, leading to pulmonary and systemic inflammation.
Yazarlar (100)
1
Qian Zhang
2
Paul Bastard
3
Adem Karbuz
4
Adrian Gervais
5
Ahmad Abou Tayoun
6
Alessandro Aiuti
7
Alexandre Belot
ORCID: 0000-0003-4902-5332
8
Alexandre Bolze
ORCID: 0000-0001-7399-2766
9
Alexandre Gaudet
10
Anastasiia Bondarenko
ORCID: 0000-0002-9737-2868
11
Zhiyong Liu
ORCID: 0000-0001-6473-348X
12
András N. Spaan
13
Andrea Guennoun
14
Andrés Augusto Arias
15
Anna M. Planas
16
Anna Sediva
17
Anna Shcherbina
18
Anna Lena Neehus
19
Anne Puel
20
Antoine Froidure
21
Antonio Novelli
22
Aslinur Ozkaya Parlakay
23
Aurora Pujol
ORCID: 0000-0002-9606-0600
24
Aysun Yahsi
25
Belgin Gulhan
ORCID: 0000-0003-0839-1301
26
Benedetta Bigio
27
Bertrand Boisson
28
Beth A. Drolet
29
Carlos Andres Arango Franco
30
Carlos Flores
31
Carlos Rodriguez-Gallego
32
Carolina Prando
33
Catherine M. Biggs
34
Charles Edouard Luyt
ORCID: 0000-0001-7424-2705
35
Clifton L. Dalgard
36
Cliona O’Farrelly
37
Daniela Matuozzo
38
David Dalmau
39
David S. Perlin
40
Davood Mansouri
41
Diederik van de Beek
42
Donald C. Vinh
43
Elena Dominguez-Garrido
44
Elena W.Y. Hsieh
45
Emine Hafize Erdeniz
46
Emmanuelle Jouanguy
ORCID: 0000-0002-7358-9157
47
Esra Sevketoglu
48
Estelle Talouarn
ORCID: 0000-0002-5016-0446
49
Eugenia Quiros-Roldan
50
Evangelos Andreakos
51
Eystein Husebye
52
Fahad M. Alsohime
53
Filomeen Haerynck
ORCID: 0000-0001-9161-7361
54
Giorgio Casari
55
Giuseppe Novelli
56
Gokhan Aytekin
57
Guillaume Morelle
ORCID: 0000-0001-6511-1674
58
Gulsum Alkan
ORCID: 0000-0003-3384-769X
59
Gulsum Iclal Bayhan
ORCID: 0000-0002-1423-4348
60
Hagit Baris Feldman
61
Helen C. Su
62
Horst von Bernuth
63
Igor Resnick
64
Ingrid G. Bustos
65
Isabelle Meyts
66
Isabelle Migeotte
67
Ivan Tancevski
68
Jacinta Bustamante
69
Jacques Fellay
70
Jamila El Baghdadi
71
Javier Martinez-Picado
72
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
73
Jérémie Rosain
74
Jeremy Manry
75
Jie Chen
76
John Christodoulou
77
Jonathan Bohlen
ORCID: 0000-0003-0458-9484
78
Jose Luis Franco
79
Juan Li
80
Juan Manuel Anaya
81
Julian Rojas
82
Junqiang Ye
83
K. M.Furkan Uddin
84
Kadriye Kart Yasar
85
Kai Kisand
86
Keisuke Okamoto
87
Khalil Chaïbi
88
Kristina Mironska
89
László Maródi
90
Laurent Abel
ORCID: 0000-0001-7016-6493
91
Laurent Renia
92
Lazaro Lorenzo
93
Lennart Hammarström
94
Lisa F.P. Ng
95
Lluis Quintana-Murci
96
Lucia Victoria Erazo
97
Luigi Notarangelo
ORCID: 0000-0002-8335-0262
98
Luis Felipe Reyes
99
Luis M. Allende
100
Luisa Imberti
Kurumlar
Academy of Athens
Athens Greece
Al Jalila Children’s Hospital
Dubai United Arab Emirates
Amsterdam Neuroscience
Amsterdam Netherlands
Ankara City Hospital
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
A-Star, Infectious Disease Lab
Singapore City Singapore
Berliner Institut für Gesundheitsforschung
Berlin Germany
Center for Discovery and Innovation
Nutley United States
Center for Infection and Immunity of Lille (CIIL)
Lille France
Centre Hospitalier Universitaire Vaudois
Lausanne Switzerland
Centre Universitaire de Santé McGill
Montreal Canada
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Madrid Spain
Charité – Universitätsmedizin Berlin
Berlin Germany
CHU de Lyon
Lyon France
CHU Lille
Lille France
Cliniques Universitaires Saint-Luc
Brussels Belgium
Collège de France
Paris France
College of Medicine
Riyadh Saudi Arabia
Columbia University
New York United States
Departement Microbiologie, Immunologie en Transplantatie
Leuven Belgium
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
Moscow Russian Federation
École Polytechnique Fédérale de Lausanne
Lausanne Switzerland
Faculdades Pequeno Príncipe
Curitiba Brazil
Fakultní Nemocnice v Motole
Prague Czech Republic
Fundació Docència i Recerca Mútua Terrassa
Terrassa Spain
Haukeland Universitetssjukehus
Bergen Norway
Helix
San Mateo United States
Holy Family Red Crescent Medical College
Dhaka Bangladesh
Hopital Avicenne
Bobigny France
Hopital de Bicetre
Le Kremlin-Bicetre France
Hôpital Necker Enfants Malades
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Hospital Universitario 12 de Octubre
Madrid Spain
Hospital Universitario Nuestra Senora de Candelaria
Santa Cruz de Tenerife Spain
Howard Hughes Medical Institute
Paris France
Institució Catalana de Recerca i Estudis Avançats
Barcelona Spain
Institut d'Investigació Biomedica de Bellvitge
Hospitalet de Llobregat Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
Barcelona Spain
Institute of Science Tokyo
Tokyo Japan
Instituto de Salud Carlos III
Madrid Spain
Instituto Tecnológico y de Energías Renovables, S.A.
Granadilla de Abona Spain
Institut Pasteur, Paris
Paris France
IRCCS Ospedale Pediatrico Bambino Gesù
Rome Italy
IRCCS Ospedale San Raffaele
Milan Italy
Karolinska Institutet
Stockholm Sweden
Konya City Hospital
Konya Turkey
KU Leuven
Leuven Belgium
KU Leuven– University Hospital Leuven
Leuven Belgium
Labor Berlin
Berlin Germany
Lee Kong Chian School of Medicine
Singapore City Singapore
L'Institut de Recherche du Centre Universitaire de Santé McGill
Montreal Canada
Medizinische Universitat Innsbruck
Innsbruck Austria
Military Hospital Mohammed V
Agdal Rabat Morocco
Mutua de Terrassa
Terrassa Spain
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
Ondokuz Mayis Üniversitesi
Samsun Turkey
Prof. Dr. Cemil Tascioglu City Hospital
Istanbul Turkey
Rioja Salud
Spain
Rockefeller University
New York United States
Selçuk Tip Fakültesi
Konya Turkey
Semmelweis Egyetem
Budapest Hungary
Shupyk National Healthcare University of Ukraine
Kyiv Ukraine
Sidra Medicine
Doha Qatar
Spedali Civili Di Brescia
Brescia Italy
SS Cyril and Methodius University Faculty of Medicine
Skopje North Macedonia
Tartu Ülikool
Tartu Estonia
Tehran University of Medical Sciences
Tehran Iran
Tel Aviv University
Tel Aviv-Yafo Israel
The University of British Columbia
Vancouver Canada
Trinity College Dublin
Dublin Ireland
Uniformed Services University of the Health Sciences
Bethesda United States
Universidad de Antioquia
Medellin Colombia
Universidad de La Sabana
Chía Colombia
Universidad del Rosario
Bogota Colombia
Universidad Fernando Pessoa Canarias
Santa Maria de Guia de Gran Canaria Spain
Università degli Studi di Brescia
Brescia Italy
Università degli Studi di Roma "Tor Vergata"
Rome Italy
Universitair Ziekenhuis Gent
Ghent Belgium
Universitat de Barcelona
Barcelona Spain
Università Vita-Salute San Raffaele
Milan Italy
Université Catholique de Louvain
Louvain-la-Neuve Belgium
Université Libre de Bruxelles
Brussels Belgium
Université Paris Cité
Paris France
University Hospital St. Marina
Varna Bulgaria
University Medical Center Utrecht
Utrecht Netherlands
University of Colorado School of Medicine
Aurora United States
University of Health Sciences
Istanbul Turkey
University of Melbourne
Melbourne Australia
University of Wisconsin School of Medicine and Public Health
Madison United States
Metrikler
249
Atıf
100
Yazar