Scopus Eşleşmesi Bulundu
413
Atıf
6
Cilt
🔓
Açık Erişim
Scopus Yazarları: H. Heinrich Hoffmann, Shohei Eto, Karita Särekannu, Paul Bastard, Tom Le Voyer, Eleftherios Michailidis, Rui Yang, Liis Haljasmägi, Yacine Tandjaoui-Lambiotte, Charles Edouard Luyt, Julien Poissy, Pascal Morel, Alexandre Belot, Jacques G. Rivière, Jean Christophe Lagier, Tomohiro Morio, Junko Tanaka, Pierre Louis Tharaux, Damien Sene, Luisa Imberti, Ottavia M. Delmonte, Andrew L. Snow, Steven M. Holland, Lazaro Lorenzo, Filomeen Haerynck, Robert Nussbaum, Sevgi Keles, Christine N. Metz, Adrian Gervais, Jérémie Rosain, Quentin Philippot, Lucy Bizien, Julia Maslovskaja, Blanca Amador-Borrero, Jesus Troya, Kahina Saker, Pierre Garçon, Lindsey B. Rosen, Juan Manuel Anaya, Paolo Bonfanti, Marcela Moncada-Velez, Soraya Boucherit, Boubacar Coulibaly, Qiang Pan-Hammarström, Alessandro Aiuti, Lucila A. Barreiros, Elena Dominguez-Garrido, Diederik van de Beek, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Jeremy Manry, Marina Garcia-Prat, Alba Parra-Martínez, Mélanie Migaud, Nicolas De Prost, Alexandre Gaudet, Pascale Richard, Fabrice Cognasse, Sophie Trouillet-Assant, Elana Shaw, Alain Stepanian, Arnaud Fekkar, Jose Luis Franco, Jordi Solé-Violán, Dany Anglicheau, Ahmed A. Bousfiha, Giorgio Casari, Fabio Ciceri, Mateus Vidigal, Mayana Zatz, Sabina Sahanic, Yurii Stepanovskyy, Yoko Nukui, Stuart G. Tangye, Stéphanie Gentile, David Dalmau, Bruno Megarbane, Vasiliki Triantafyllia, James R. Heath, Andrea Biondi, Riccardo Castagnoli, Yu Zhang, Catherine M. Biggs, Andrés Augusto Arias, Anna M. Planas, Sotirija Duvlis, Tayfun Ozcelik, Jalila El Bakkouri, Carolina Ramirez-Santana, Stéphane Paul, Lennart Hammarström, Annabelle Dupont, Alina Kurolap, Vito Lampasona, Ivan Tancevski, Oksana Boyarchuk, Miyuki Tsumura, Loreto Vidaur, Sonia Burrel
Özet
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.
Makale Bilgileri
Dergi
Science Immunology
ISSN
2470-9468
Yıl
2021
/ 8. ay
Cilt / Sayı
6
/ 62
Sayfalar
1 – 26
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q1
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
1122 kişi
Erişim Türü
Basılı+Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı>Çocuk Sağlığı ve Hastalıkları
YÖKSİS Yazar Kaydı
Yazar Adı
Bastard Paul, Gervais Adrian, Voyer Tom Le, Rosain Jérémie, Rosain Jérémie, Philippot Quentin, Manry Jérémy, Michailidis Eleftherios, Hoffmann Hans-Heinrich, Eto Shohei, Garcia-Prat Marina, Bizien Lucy, Parra-Martínez Alba, Yang Rui, Haljasmägi Liis, Migaud Mélanie, Särekannu Karita, Maslovskaja Julia, de Prost Nicolas, Tandjaoui-Lambiotte Yacine, Luyt Charles-Edouard, Amador-Borrero Blanca, Gaudet Alexandre, Poissy Julien, Morel Pascal, Richard Pascale, Cognasse Fabrice, Troya Jesus, Trouillet-Assant Sophie, Belot Alexandre, Saker Kahina, Garçon Pierre, Rivière Jacques G., Lagier Jean-Christophe, Gentile Stéphanie, Rosen Lindsey B., Shaw Elana, Morio Tomohiro, Tanaka Junko, Dalmau David, Tharaux Pierre-Louis, Sene Damien, Stepanian Alain, Megarbane Bruno, Triantafyllia Vasiliki, Fekkar Arnaud, Heath James R., Franco José, Anaya Juan-Manuel, Solé-Violán Jordi, Imberti Luisa, Biondi Andrea, Bonfanti Paolo, Castagnoli Riccardo, Delmonte Ottavia M., Zhang Yu, Snow Andrew L., Holland Steven M., Biggs Catherine M., Moncada-Vélez Marcela, Arias Andrés Augusto, Lorenzo Lazaro, Boucherit Soraya, Coulibaly Boubacar, Anglicheau Dany, Planas Anna M., Haerynck Filomeen, Duvlis Sotirija, Nussbaum Robert L., ÖZÇELİK HASAN TAYFUN, KELEŞ SEVGİ, Bousfiha Ahmed A., El Bakkouri Jalila, Ramirez-Santana Carolina, Paul Stéphane, Pan-Hammarström Qiang, Hammarström Lennart, Dupont Annabelle, Kurolap Alina, Metz Christine N., Aiuti Alessandro, Casari Giorgio, Lampasona Vito, Ciceri Fabio, Barreiros Lucila A., Dominguez-Garrido Elena, Vidigal Mateus, Zatz Mayana, van de Beek Diederik, Sahanic Sabina, Tancevski Ivan, Stepanovskyy Yurii, Boyarchuk Oksana, Nukui Yoko, Tsumura Miyuki, Vidaur Loreto, Tangye Stuart G., Burrel Sonia, Duffy Darragh, Quintana-Murci Lluis, Klocperk Adam, Kann Nelli Y., Shcherbina Anna, Lau Yu-Lung, Leung Daniel, Coulongeat Matthieu, Marlet Julien, Koning Rutger, Reyes Luis Felipe, Chauvineau-Grenier Angélique, Venet Fabienne, Monneret Guillaume, Nussenzweig Michel C., Nussenzweig Michel C., Arrestier Romain, Boudhabhay Idris, Baris-Feldman Hagit, Hagin David, Wauters Joost, Meyts Isabelle, Dyer Adam H., Kennelly Sean P., Bourke Nollaig M., Halwani Rabih, Sharif-Askari Narjes Saheb, Dorgham Karim, Sallette Jérome, Sedkaoui Souad Mehlal, AlKhater Suzan, Rigo-Bonnin Raúl, Morandeira Francisco, Roussel Lucie, Vinh Donald C., Ostrowsk Sisse Rye, Condino-Neto Antonio, Prando Carolina, Bondarenko Anastasiia, Spaan András N., Gilardin Laurent, Fellay Jacques, Lyonnet Stanislas, Bilguvar Kaya, Lifton Richard P., Mane Shrikant, Bigio Benedetta, Boucherit Soraya, de la Chapelle Aliénor, Chen Jie, Chrabieh Maya, Coulibaly Boubacar, Liu Dana, Nemirowskaya Yelena, Cruz Inés Marín, Materna Marie, Pelet Sophie, Seeleuthner Yoann, Thibault Chloé, Liu Zhiyong, Abad Jorge, Accordino Giulia, Achille Cristian, Aguilera-Albesa Sergio, Aguiló-Cucurull Aina, AIUTI Alessandro, AKYÜZ ÖZKAN ESRA, Darazam Ilad Alavi, Albisures Jonathan Antonio Roblero, Aldave Juan C., Ramos Miquel Alfonso, Khan Taj Ali, Aliberti Anna, Nadji Seyed Alireza, ALKAN GÜLSÜM, AlKhater Suzan A., Allardet-Servent Jerome, Allende Luis M., ALONSO-ARIAS Rebeca, Alshahrani Mohammed S., Alsina Laia, Alyanakian Marie-Alexandra, Borrero Blanca Amador, Amoura Zahir, Antolí Arnau, Arrestier Romain, Aubart Mélodie, Auguet Teresa, Avramenko Iryna, AYTEKİN GÖKHAN, Azot Axelle, Bahram Seiamak, Bajolle Fanny, Baldanti Fausto, Baldolli Aurélie, Ballester Maite, Feldman Hagit Baris, Barrou Benoit, BARZAGHI Federica, Basso Sabrina, BAYHAN GÜLSÜM İCLAL
YÖKSİS ID
5671774
Hızlı Erişim
Metrikler
Scopus Atıf
413
JCR Quartile
Q1
Yazar Sayısı
1122