Scopus
Effects of percutaneous laser ablation treatment in benign solitary thyroid nodules on nodule volume, thyroglobulin and anti-thyroglobulin levels, and cytopathology of nodule in 1 yr follow-up
Journal of Endocrinological Investigation · Ocak 2006
Makale Bilgileri
DergiJournal of Endocrinological Investigation
Yayın TarihiOcak 2006
Cilt / Sayfa29 · 876-884
Scopus ID2-s2.0-33846483180
Özet
Objective: To investigate the effects of ultrasound (US)-guided percutaneous laser ablation (PLA) in the treatment of benign solid hypoactive thyroid nodules on nodule volume, thyroid functions, nodule cytology and patients' complaints. Material and method: Criteria for enrollment in the study were as follows: patients with euthyroid. benign, hypofunctional nodule who had compressive symptoms or cosmetic complaints, but considered inoperable, or who rejected surgical treatment. PLA procedure at 3-5 watts (W) was applied to 15 thyroid nodules of 12 patients (4 male and 8 female; age range 20-78 yr, mean age 47.42±17.05 yr), and patients were followed up for 12 months. Thyroid functions and nodule volumes (ultrasonographically) were evaluated. US-guided fine needle aspiration biopsy (FNAB) was performed before and after the procedure, and biopsy specimens were cytologically evaluated. Results: The mean nodule volume before the procedure was 11.97 ml (min-max 0.95-26.30 ml). However, 12 months after the procedure the mean nodule volume was 2.21±2.32 ml (min-max 0.10-7.65 ml). The mean reduction in nodule volumes was 82%. Thyroglobulin levels reached peak values at 1 month after the procedure, and anti-thyroglobulin levels at 3 months after the procedure. FNAB performed at 12th month showed neutrophil polymorphs. macrophages, abundant cell debris, colloid, multinucleated giant cells, and small fragments of fibrous stroma which indicated that PLA procedure led to degenerative changes in nodules. Conclusion: US-guided PLA is a new, successful treatment method which is reliable in the long term in benign solid thyroid nodules for selected patients who are inoperable or do not prefer surgery. ©2006, Editrice Kurtis.
Yazarlar (10)
1
Bekir Cakir
2
Oya Topaloglu
3
Kamile Gul
4
Tuba Agac
5
Cevdet Aydin
6
Ahmet Dirikoc
7
Mehmet Gümüş
8
K. Yazicioglu
9
R. Ersoy
10
Serdar Uğraş
Anahtar Kelimeler
Hypofunctioning solid thyroid nodules
Nodule cytopathology
Nodule volume
Percutaneuous laser ablation
Thyroglobulin and antithyroglobulin
Kurumlar
Ankara Numune Education and Research Hospital
Ankara Turkey
Ataturk Training and Research Hospital
Izmir Turkey
Metrikler
53
Atıf
10
Yazar
5
Anahtar Kelime