Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Ultrasonographic evaluation of thyroid nodules: Comparison of ultrasonographic, cytological, and histopathological findings
Endocrine · Ocak 2009
YÖKSİS Kayıtları
Ultrasonographic evaluation of thyroid nodules comparison of ultrasonographic cytological and histopathological findings
Endocrine · 2009 SCI
Prof. Dr. NEVZAT SERDAR UĞRAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis
2015 ISSN: 1355-008X SCI-Expanded 2 atıf
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Ultrasonographic evaluation of thyroid nodules comparison of ultrasonographic cytological and histopathological findings
2009 ISSN: 1355-008X SCI
Prof. Dr. NEVZAT SERDAR UĞRAŞ →
Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism.
2019 ISSN: 1355-008X SCI
Doç. Dr. MUAMMER BÜYÜKİNAN →
Makale Bilgileri
Dergi
Endocrine
ISSN1355008X
Yayın TarihiOcak 2009
Cilt / Sayfa36 · 464-472
Scopus ID2-s2.0-70449519971
Özet
Thyroid ultrasonography (US) and fine needle aspiration biopsy (FNAB) are the most important tools in evaluating thyroid nodules. A total of 3,404 nodules in 2,082 cases referred to our clinic between 2005 and 2008 were analyzed retrospectively. Considering US features of nodules, risk factors predicting malignancy were: margin irregularity as the most important predictor, hypoechoic pattern and microcalcification (Odds ratios: 63.2, 13.3, 7.03, respectively). Cytologic results of the patients were as follows: 1,718 (82.5%) benign, 196 (9.4%) suspicious, 68 (3.3%) nondiagnostic, and 100 (4.8%) malignant. In histopathologic examination, we determined a malignancy rate of 7.59% (158/2082). We calculated the sensitivity of FNAB as 89.16%, specificity as 98.77%, positive predictive value as 96.10%, negative predictive value as 96.39%, and accuracy as 96.32%. In cytologic examination, the malignancy rate of subcentimetric (≤1 cm) nodules was higher than supracentimetric (>1 cm) nodules (5.1% vs. 1.5%, P = 0.001). In postoperative histopathologic examination, although the malignancy rate of subcentimetric nodules was higher than that of supracentimetric nodules, the difference was statistically insignificant (5.5%, 4.4%, respectively; P > 0.05). Cytologically diagnosed malignancy was detected in 4.5% of patients with multiple nodules, while it was present in 6% of patients with solitary nodule indicating no significant difference. However, postoperative histopathologic examination revealed a significantly higher malignancy rate in patients with solitary nodule compared to in patients with multiple nodules (11.7%, 6.5%; respectively, P < 0.001). The malignancy rate of patients operated for suspicious cytology was found to be 46.15%; for nondiagnostic cytology, it was 64.29%. In conclusion, ultrasonographically, hypoechoic pattern, microcalcification and margin irregularity of thyroid nodules are important features in determining the malignancy risk. The nodule size alone still remains inadequate to exclude malignancy risk. © 2009 Humana Press.
Yazarlar (9)
1
Kamile Gul
2
R. Ersoy
3
Ahmet Dirikoc
4
Birol Korukluoglu
5
Pamir Eren Ersoy
6
Raci Aydin
7
Serdar Uğraş
8
Olcay Belenli
9
Bekir Cakir
Anahtar Kelimeler
Cytology
Fine needle aspiration biopsy
Histopathology
Ultrasonography
Kurumlar
Ataturk Training and Research Hospital
Izmir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Endocrine
Q2
SJR Skoru0,971
H-Index107
YayıncıSpringer
ÜlkeUnited States
Endocrinology (Q2)
Endocrinology, Diabetes and Metabolism (Q2)
Metrikler
61
Atıf
9
Yazar
4
Anahtar Kelime