Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: Similarities and differences
Pediatric Allergy and Immunology · Ağustos 2010
YÖKSİS Kayıtları
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia Similarities and differences
Pediatric Allergy and Immunology · 2010 SCI
Prof. Dr. HASİBE ARTAÇ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Transient Hypogammaglobulinemia and Unclassified Hypogammaglobulinemia: 'Similarities and Differences'
2010 ISSN: 0905-6157 SCI-Expanded 20 atıf
Öğr. Gör. REYHAN KARA →
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia Similarities and differences
2010 ISSN: 09056157 SCI
Prof. Dr. HASİBE ARTAÇ →
Relationship of advanced glycation end products with disease severity in breast‐fed infants with atopic dermatitis
2024 ISSN: 0905-6157 SCI-Expanded Q2
Prof. Dr. HASİBE ARTAÇ →
Variable clinical presentation of hypomorphic DCLRE1C deficiency from childhood to adulthood
2024 ISSN: 0905-6157 SCI-Expanded Q2
Prof. Dr. HASİBE ARTAÇ →
Makale Bilgileri
ISSN09056157
Yayın TarihiAğustos 2010
Cilt / Sayfa21 · 843-851
Scopus ID2-s2.0-77954899861
Özet
Transient hypogammaglobulinemia of infancy (THI) is characterized by recurrent infections and one or more reduced serum immunoglobulin (Ig) levels. Usually, this clinical picture resolves spontaneously by 3 yr of age. However, hypogammaglobulinemia persists until adolescence in some patients. In recent years, those patients have been classified as undefined/unclassified hypogammaglobulinemia (UCH). We aimed to evaluate the clinical and immunologic features of patients with THI and UCH considering age of recovery and to assess relationships between hypogammaglobulinemia, infections, and allergic manifestations. We reviewed the medical records of children followed with a diagnosis of hypogammaglobulinemia from 2001 to 2007. Patients with decreased levels (<2 s.d.) of one or more major Ig isotypes (IgG, IgA, IgM) with normal antibody responses and lymphocyte subpopulations were included (n = 374). Those patients whose Igs normalized during the follow-up period were classified as THI and the others as UCH. The THI group consisted of 71 patients (27 females, 44 males) with a mean recovery age of 68.87 ± 36.5 months. About 95% of patients with THI recovered before 10 yr of age. The UCH group consisted of 303 patients (105 females, 198 males) with a mean age at diagnosis of 52 ± 42 months. The most common presenting manifestations in the THI and UCH groups were upper respiratory tract infections (URTIs), lower respiratory tract infections, and asthma (42%, 50%, and 52% in the THI group vs. 39%, 53%, and 55% in the UCH group, respectively). In the THI group, the prevalence of atopic disease was related to age and found to be increased markedly after 44 months. In all patients, the prevalence of asthma was independently and positively associated with family history of atopy and age, whereas it was negatively associated with recurrent URTIs. Patients with THI and UCH have similar clinical and immunologic features. The normalization of Igs may be delayed in a majority of the patients with hypogammaglobulinemia. This observation may be a contribution to the classical definition and diagnostic criteria for THI. © 2010 John Wiley & Sons A/S.
Yazarlar (6)
1
Sevgi Keles
2
Hasibe Artac
3
Reyhan Kara
4
Bahar Gokturk
5
Ahmet Ozen
6
Ismail Reisli
Anahtar Kelimeler
allergy
children
primary immunodeficiency
transient hypogammaglobulinemia of infancy
unclassified hypogammaglobulinemia
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Yeditepe University
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pediatric Allergy and Immunology
Q1
SJR Skoru1,226
H-Index112
YayıncıBlackwell Munksgaard
ÜlkeUnited Kingdom
Pediatrics, Perinatology and Child Health (Q1)
Immunology (Q2)
Immunology and Allergy (Q2)
Metrikler
49
Atıf
6
Yazar
5
Anahtar Kelime