Scopus
YÖKSİS Eşleşti
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy
Clinical and Experimental Medicine · Kasım 2013
YÖKSİS Kayıtları
Reduced CD19 Expression and Decreased Memory B Cell Numbers in Transient Hypogammaglobulinemia of Infancy
Clinical and Experimental Medicine · 2013 SCI-Expanded 9 atıf
ÖĞRETİM GÖREVLİSİ REYHAN KARA →
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy
Clinical and Experimental Medicine · 2013 SCI-Expanded
PROFESÖR HASİBE ARTAÇ →
Makale Bilgileri
DergiClinical and Experimental Medicine
Yayın TarihiKasım 2013
Cilt / Sayfa13 · 257-263
Scopus ID2-s2.0-84888355731
Özet
We aimed to evaluate the role of the CD19 complex in the pathogenesis of transient hypogammaglobulinemia of infancy (THI) and to better characterize the subsets of memory B cells. The study population consisted of 22 male and 14 female patients with a mean age at presentation of 20 ± 9.9 months. The CD19 complex and B cell subsets were evaluated by flow cytometry. While the CD19 median fluorescence index (MFI) in patients with THI was significantly lower than controls (122.9 ± 66.7 in patients; 184.2 ± 39 in controls, p < 0.01), expression of CD21 and CD81 was increased (94.4 ± 3, 96.8 ± 2.5 % in patients; 91 ± 3.9; 94.7 ± 3.5 % in controls, p < 0.01 vs. p < 0.05, respectively). The expressions of switched memory B cells and IgM memory B cells were found to be reduced in THI. Considering that the CD19 complex regulates the events following antigen stimulation, the change in CD19 complex detected in THI may be related to insufficiency of antibody production. © 2012 Springer-Verlag.
Yazarlar (4)
1
Hasibe Artac
2
Reyhan Kara
3
Bahar Gokturk
4
Ismail Reisli
Anahtar Kelimeler
CD19 complex
Memory B cells
Transient hypogammaglobulinemia of infancy
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
12
Atıf
4
Yazar
3
Anahtar Kelime