Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Safety assessment of the innovative functional food ingredient from Cannabis sativa L. wastes
Eurobiotech Journal · Temmuz 2020
YÖKSİS Kayıtları
Safety assessment of the innovative functional food ingredient from Cannabis sativa L. wastes
The EuroBiotech Journal · 2020 ESCI
DOÇENT SALİHA DİNÇ →
Safety assessment of the innovative functional food ingredient from Cannabis sativa L. wastes
The EuroBiotech Journal ESCI
DOÇENT SALİHA DİNÇ →
Makale Bilgileri
DergiEurobiotech Journal
Yayın TarihiTemmuz 2020
Cilt / Sayfa4 · 134-143
Scopus ID2-s2.0-85107568257
Erişim🔓 Açık Erişim
Özet
Xylooligosaccharides (XOS) are the oligomers of β-1,4 linked xylose monomers and they have health promoting effect by modulating the beneficial microorganisms in intestine. In this study, hydrolysate obtained from hemp (Cannabis sativa) shives was investigated in terms of its in vitro toxicological impacts at cellular and genetic levels and antioxidant activity. The hydrolysate was found to contain 0.264 mg mL-1 of xylose, 0.789 mg mL-1 of xylobiose and 0.171 mg mL-1 of xylotriose in addition to hydroxymethlyfurfural (HMF) and furfural (F) at concentrations of 0.545 mg mL-1 and 0.107 mg mL-1, respectively. The cells, colon epithelial cells (CoN) and colon cancer cells (Caco-2), exposed to 5.00 mg mL-1 or lower XOS hydrolysate showed very similar growth profiles to the untreated control cells. At the genetic level, the oxidative responses of the cell types to XOS hydrolysate were different as measured by NFE2L2 (Nuclear factor, erythroid-derived 2-like 2) gene expression. Regarding antioxidant activity, the amount of XOS hydrolysate (IC50) that cleared 50 % of the 2,2-diphenyl-l-picrylhydrazyl (DPPH) in the medium was calculated as 0.12 mg mL-1. To conclude, based on in vitro studies, XOS hydrolysate obtained from lignocellulosic hemp shives emerges as an innovative, alternative and safe functional food candidate.
Yazarlar (8)
1
Fatmanur Gönce
2
Elmas Ersöz
3
Meryem Kara
4
Gökhan Kars
ORCID: 0000-0002-2507-2305
5
Saliha Dinç
6
Serpil Edebali
7
Manuel Roman
8
Meltem Demirel Kars
Anahtar Kelimeler
Cannabis sativa L.
Colon cancer
cytotoxicity
functional food
hemp shives
xylooligosaccharides
Kurumlar
CONTACTICA SL
Madrid Spain
Isanatur S.L.
Navarra Spain
Konya Technical University
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
8
Yazar
6
Anahtar Kelime