Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
NMR-based plasma metabolomics at set intervals in newborn dairy calves with severe sepsis
Mediators of Inflammation · Ocak 2018
YÖKSİS Kayıtları
NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis
Mediators of Inflammation · 2018 SCI-Expanded
DOÇENT AMİR NASERİ →
Makale Bilgileri
DergiMediators of Inflammation
Yayın TarihiOcak 2018
Cilt / Sayfa2018
Scopus ID2-s2.0-85053726254
Erişim🔓 Açık Erişim
Özet
The aim of this first study was to reveal the new potential biomarkers by a metabolomics approach in severe septic calves. Sepsis is a common cause of morbidity and mortality in newborn dairy calves. The main challenges with the use of biomarkers of sepsis in domestic animals are their availability, cost, and time required to obtain a result. Metabolomics may offer the potential to identify biomarkers that define calf sepsis in terms of combined clinical, physiological, and pathobiological abnormalities. To our knowledge, this is the first study presenting an NMR-(nuclear magnetic resonance-) based plasma metabolomics at set intervals in neonatal septic calves. Twenty neonatal dairy calves with severe sepsis and ten healthy calves were used. Hematological and biochemical health profiles were gathered in plasma samples at set intervals. Similarly, NMR spectra were acquired. All diseased animals (except one) died after 72 hours. Clinical and laboratory results were in accordance with those of severe septic animals. Multivariate analysis on NMR plasma spectra proved to be an excellent tool for faster identification of calves with severe sepsis from healthy animals. The NMR-based metabolomic profile may contribute to the better understanding of severe sepsis in newborn calves.
Yazarlar (5)
1
Abdullah Başoğlu
2
Ismail Sen
3
Gaia Meoni
4
Leonardo Tenori
5
Amir Naseri
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Firenze
Florence Italy
Università degli Studi di Firenze, Facoltà di Medicina e Chirurgia
Florence Italy
Metrikler
20
Atıf
5
Yazar