Scopus
🔓 Açık Erişim
Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock
Ankara Universitesi Veteriner Fakultesi Dergisi · Haziran 2023
Makale Bilgileri
DergiAnkara Universitesi Veteriner Fakultesi Dergisi
Yayın TarihiHaziran 2023
Cilt / Sayfa70 · 327-335
Scopus ID2-s2.0-85163625702
Erişim🔓 Açık Erişim
Özet
The goal of this study was to see how to evaluate the changes in macrovascularand microvascular parameters in survivors (Sv) and non-survivors (non-Sv) dogs with severe sepsis and septic shock (SEVS & SEPS) in response to goal-directed hemodynamic optimization at the intensive care unit (ICU), and to evaluate norepinephrine (NE) and dobutamine (DT) ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SEVS & SEPS were used. NE was given to 10 hypotensive dogs, despite receiving a single bolus of fluid therapy, at a constant infusion rate of 1.5 µg/kg/min for 2 h. The rate of NE infusion was doubled (3.0 µg/kg/min) if the clinical response was insufficient after 2 hours. DT was administered to 5 dogs with left ventricular systolic dysfunction (LVSD) (LVS’<7.5 cm/s) at a constant infusion rate of 5 µg/kg/min for 2 h. The Sv and non-Sv groups had no major differences in macrovascular and microvascular characteristics, PW-TDI septal mitral annulus systolic (S') and early diastolic (E') velocities, or DT applications. The only difference was the use of NE applications. non-Sv received a greater amount of NE, while Sv received a smaller amount of NE. In contrast, more Sv received a greater amount of DT applications. Total mortality rate was 25.7%. In conclusion, the effects of DT and NE in dogs with SEVS & SEPS are limited. To provide evidence-based guidelines for dogs with SEVS & SEPS, more research is needed.
Yazarlar (5)
1
Havva Süleymanoğlu
ORCID: 0000-0002-6681-0212
2
Kursad Turgut
3
Merve Ertan
ORCID: 0000-0003-3436-4817
4
Mehmet Ege Ince
5
Amir Naseri
Anahtar Kelimeler
Dobutamine
Early goal-directed therapy
Norepinephrine
Septic shock
Severe sepsis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Yakın Doğu Üniversitesi
Nicosia Cyprus
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime