Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Determination of the embryotoxic effect of Metronidazole using an in ovo model
Revista Cientifica de la Facultad de Veterinaria · Ocak 2024
YÖKSİS Kayıtları
Determination of the embryotoxic effect of Metronidazole using an in ovo model
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
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Makale Bilgileri
DergiRevista Cientifica de la Facultad de Veterinaria
Yayın TarihiOcak 2024
Cilt / Sayfa34
Scopus ID2-s2.0-85185493731
Erişim🔓 Açık Erişim
Özet
Metronidazole is an imidazole group bactericidal antibiotic used against anaerobic bacteria and some protozoa. There is no detailed information about the embryotoxic effect of Metronidazole. This study aims to determine the embryotoxic activity of Metronidazole using an in ovo method. A total of 210 fertile chicken eggs were placed in an incubator, divided into seven equal groups of 30. The first group was considered as the control group. On the seventh day of the study, Metronidazole was administered to the other six groups within 50 μL saline solution at doses of 250, 125, 62.5, 31.25, and 15.62 μg·egg-1 (5; 2.5; 1.25; 0.625; 0.312 mg·kg-1). At the end of the incubation period, the eggs hatched, and the number of live and dead embryos was determined. There were no significant differences in deaths between the groups (P>0.05 in all cases). No anomaly was detected in the macroscopic morphology of the embryos. As a result, it can be stated that Metronidazole may be safe for use during pregnancy. However, it is necessary to conduct molecular and histopathological studies to investigate the effects of this drug on organogenesis, especially in mammalian embryos.
Yazarlar (4)
1
Muhittin Uslu
ORCID: 0000-0002-9027-4229
2
Rahmi Canbar
ORCID: 0000-0001-7100-4437
3
Mustafa Sedat Arslan
ORCID: 0000-0002-4079-500X
4
Harun Kızılay
ORCID: 0000-0003-3660-0721
Anahtar Kelimeler
embryotoxicity
in ovo
Metronidazole
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey