Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Evaluation of Histopathological Effects of Acamprosate Use on Kidneys in Alcohol-Dependent Rats
Turkish Journal of Nephrology · Ekim 2023
YÖKSİS Kayıtları
Evaluation of Histopathological Effects of Acamprosate Use on Kidneys in Alcohol-Dependent Rats
AVES YAYINCILIK A.Ş. · 2023 Emerging Sources Citation Index
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Makale Bilgileri
DergiTurkish Journal of Nephrology
Yayın TarihiEkim 2023
Cilt / Sayfa32 · 346-352
Scopus ID2-s2.0-85176209799
Erişim🔓 Açık Erişim
Özet
Objective: Alcohol addiction is one of the growing global addiction threads. The present study aims to investigate histopathological effects of acamprosate, which is widely used in the treatment of alcohol dependence, on kidneys. Methods: Rats were divided into 4 groups. The control group was given 10 mg/kg/day saline, and the alcohol group was given 10 mg/kg/day ethanol, diluted with 10 mg/kg/day saline. To the acamprosate group, 200 mg/kg/day acamprosate diluted with 10 mg/kg/day saline was given. The alcohol + acamprosate group was given 10 mg/kg/day ethanol diluted with 10 mg/kg/day saline, then combined with 200 mg/kg/day acamprosate. On the 21st day, after the study began, signs of alcohol withdrawal syndrome in the rats were evaluated. On the 22nd day, kidney tissues of the rats were extracted. Results: Histopathological evaluation revealed that kidney tissues of the control group had normal structure. It was determined that Bowman’s spaces were close to normal in kidneys of the alcohol group. In kidneys of the acamprosate group, an increased Bowman's space distance and intense tubular degeneration, shedding in tubule epithelial cells, and tubular dilatation were detected (P < .05). In kidneys of the alcohol + acamprosate group, Bowman's space distance was better than the acamprosate group, but tubular degeneration, shedding in tubule epithelial cells, and tubular dilatation continued (P < .05). Our findings revealed that the use of acamprosate alone produced serious histopathological consequences for kidneys. Conclusion: It has been understood that it is important to control kidney health at certain intervals during the period of alcohol-dependent individuals without any kidney disease receiving acamprosate treatment.
Yazarlar (5)
1
Faik Özdengül
2
Burcu Gültekin
ORCID: 0000-0001-6461-8123
3
Hande Küsen
4
Behiye Nur Karakuş
5
Aysu Şen
Anahtar Kelimeler
Acamprosate
acamprosate treatment
alcohol
kidney
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Metrikler
1
Atıf
5
Yazar
4
Anahtar Kelime