Scopus
Abdominal Ischemia-Reperfusion Induced Cardiac Dysfunction Can Be Prevented by MitoTEMPO
Journal of Investigative Surgery · Ocak 2022
Makale Bilgileri
DergiJournal of Investigative Surgery
Yayın TarihiOcak 2022
Cilt / Sayfa35 · 577-583
Scopus ID2-s2.0-85103208635
Özet
Background: Cardiac dysfunction is secondary to acute mesenteric ischemia (AMI) and abdominal aortic aneurysms (AAA). The underlying cause of distant organ damage in the heart is the formation of oxidative stress caused by ischemia-reperfusion. In this study, we investigated the possible protective effects of a novel mitochondria-targeted antioxidant MitoTEMPO on contractile dysfunction and structural defects of the rat papillary muscle caused by abdominal ischemia-reperfusion (AIR). Methods and Results: In the experiments, adult Wistar-Albino rats were used and animals were divided randomly into 3 groups; sham-operated group (SHAM), an IR group that had aortic cross-clamping for 1 h followed by 2 h reperfusion, and a third group that received protective 0.7 mg/kg/day MitoTEMPO injection for 28-day before IR. As a result, it was observed that MitoTEMPO injection had a protective effect on the mechanical activities and structural properties of the papillary muscle impaired by AIR. Our study also showed that AIR disrupted the contractile function of the papillary muscle for each stimulation frequency and post-potentiation responses tested. This is common for each measured and calculated mechanical parameter and MitoTEMPO injection showed its protective effects. Conclusion: Consequently, calcium homeostasis seems to be impaired by AIR, and MitoTEMPO may exert its protective effect through energy metabolism by directly targeting the mitochondria.
Yazarlar (4)
1
Ahmet Akkoca
ORCID: 0000-0001-8269-9385
2
Murat Cenk Celen
ORCID: 0000-0003-0727-0110
3
Seckin Tuncer
4
Nizamettin Dalkilic
Anahtar Kelimeler
ischemia-reperfusion
MitoTEMPO
muscle contraction
papillary muscle
Kurumlar
Başkent Üniversitesi
Ankara Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
4
Yazar
4
Anahtar Kelime