Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of ginseng and echinacea on cytokine mRNA expression in rats
The Scientific World Journal · Ocak 2012
YÖKSİS Kayıtları
Effects of Ginseng and Echinacea on Cytokine mRNA Expression in Rats
The Scientific World Journal · 2012 SCI
PROFESÖR DENİZ ULUIŞIK →
Effects of Ginseng and Echinacea on Cytokine mRNA Expression in Rats
The Scientific World Journal · 2012 SCI
PROFESÖR ERCAN KESKİN →
Makale Bilgileri
DergiThe Scientific World Journal
Yayın TarihiOcak 2012
Cilt / Sayfa2012
Scopus ID2-s2.0-84878763381
Erişim🔓 Açık Erişim
Özet
The aim of the study was to determine the effect of ginseng and echinacea on the mRNA expression of IL-10, TNF-α, and TGF-β1 in healthy rats. Six-week-old male Fischer 344 rats (n = 48) were used. The animals were divided into three equal groups, as follows: control (C); ginseng (G); echinacea (E). While the C group was fed a standard rat diet (Purina) ad libitum for a period of 40 days, the G and E groups animals received the same diet containing 0.5g/kg of Panax ginseng root powder and 0.75g/kg of Echinacea purpurea root powder, respectively. Blood samples were obtained from 8 rats in each group after 20 and 40 days of treatment, and the mRNA expression of IL-10, TNF-α, and TGF-β1 was determined. After 20 days of treatment, the expression of IL-10 mRNA in the G group was different from the C group (P 0.05); however, after 40 days of treatment, there was no difference between the groups. There was no difference after 20 and 40 days of treatment between the groups with respect to the expression of TGF-β1 mRNA. After 20 days of treatment, the expression of TNF- mRNA in the E group was higher (P 0.05) than the C group. After 40 days of treatment, the expression of TNF- mRNA was similar in all of the groups. Based on the current study, the increase in expression of IL-10 mRNA in the G group and the increase in expression of TNF- mRNA in the E group support the use of these plants for purposes of modulating the immune system. However, a more detailed study regarding the effects of ginseng and echinacea on these cytokines and other cytokines is needed. Copyright © 2012 Deniz Uluk and Ercan Keskin.
Yazarlar (2)
1
Deniz Uluíşik
2
E. Keskin
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
2
Yazar