Scopus
YÖKSİS Eşleşti
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
International Journal of Biological Macromolecules · Aralık 2017
YÖKSİS Kayıtları
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
International Journal of Biological Macromolecules · 2017 SCI
PROFESÖR İDRİS SARGIN →
Makale Bilgileri
DergiInternational Journal of Biological Macromolecules
Yayın TarihiAralık 2017
Cilt / Sayfa105 · 749-756
Scopus ID2-s2.0-85025159761
Özet
Sporopollenin is a promising material for drug encapsulation due to its excellent properties; uniformity in size, non-toxicity, chemically and thermally resilient nature. Herein, morphologically intact sporopollenin microcapsules were extracted from Betula pendula pollens. Cancer therapeutic agent (imatinib mesylate) was loaded into the microcapsules. The encapsulation efficiency by passive loading technique was found to be 21.46%. Release behaviour of the drug from microcapsules was found to be biphasic, with an initial fast release followed by a slower rate of release. Imatinib mesylate release from the drug itself (control) was faster than from imatinib mesylate-loaded sporopollenin microcapsules. The release profiles for both free and entrapped drug samples were significantly slower and more controlled in PBS buffer (pH 7.4) than in HCl (pH 1.2) buffer. Cumulative drug release from IM-MES-loaded sporopollenin microcapsules was found to be 65% within 24 h for PBS, whereas release from the control was completed within 1 h. Also, a complete dissolution of control in HCl buffer was observed within first 30 min. MTT assay revealed that drug-loaded microcapsules were effective on WiDr human colon carcinoma cell line. B. pendula sporopollenin can be suggested as an effective carrier for oral delivery of imatinib mesylate.
Yazarlar (9)
1
Idris Sargin
ORCID: 0000-0003-3785-9575
2
Lalehan Akyuz
3
Murat Kaya
4
G. Tan
5
Talip Ceter
6
Kevser Yildirim
7
Seymanur Ertosun
8
Gozde Hatun Aydin
9
Muge Topal
Anahtar Kelimeler
Encapsulation
Microcapsule
Oral drug delivery
Pollen
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Kastamonu University
Kastamonu Turkey
Metrikler
35
Atıf
9
Yazar
4
Anahtar Kelime