Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
International Journal of Biological Macromolecules · Aralık 2017
YÖKSİS Kayıtları
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
International Journal of Biological Macromolecules · 2017 SCI
Prof. Dr. İDRİS SARGIN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 0141-8130 SCI 2 atıf
Prof. Dr. MUSTAFA ÖZMEN →
Binding of actin to thioglycolic acid modified superparamagnetic nanoparticles for antibody conjugation
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 01418130 SCI-Expanded 1 atıf
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. SALİH ZEKİ BAŞ →
Immobilization of Candida rugosa lipase on sporopollenin from Lycopodium clavatum
2009 ISSN: 0141-8130 SCI-Expanded
Prof. Dr. ELİF ÖZYILMAZ →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Synthesis and characterization of novel nano chitosan Schiff base and use of lead II sensor
2012 ISSN: 01418130 SCI-Expanded 7 atıf
Prof. Dr. SEMAHAT KÜÇÜKKOLBAŞI →
Chitosan sporopollenin microcapsules Preparation characterisation and application in heavy metal removal
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. GÜLŞİN ARSLAN →
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 01418130 SCI-Expanded 1 atıf
Prof. Dr. İLKAY HİLAL GÜBBÜK →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded 2 atıf
Prof. Dr. MUSTAFA ÖZMEN →
Characteristics of corneal lens chitin in dragonfly compound eyes
2016 ISSN: 01418130 SCI
Prof. Dr. GÜLŞİN ARSLAN →
Evaluation of antibacterial properties on polysulfone composite membranes using synthesized biogenic silver nanoparticles with Ulva compressa (L.) Kütz. and Cladophora glomerata (L.) Kütz. extracts
2018 ISSN: 01418130 SSCI
Prof. Dr. MUSTAFA ERSÖZ →
Supplementing capsaicin with chitosan-based films enhanced the anti-quorum sensing, antimicrobial, antioxidant, transparency, elasticity and hydrophobicity
2018 ISSN: 0141-8130 SCI
Prof. Dr. İDRİS SARGIN →
Characteristics of corneal lens chitin in dragonfly compound eyes
2016 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Chitin extraction and characterization from Daphnia magna resting eggs
2013 ISSN: 0141-8130 SCI
Prof. Dr. İDRİS SARGIN →
Chitosan nanofiber production from Drosophila by electrospinning
2016 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Chitosan/sporopollenin microcapsules: Preparation, characterisation and application in heavy metal removal
2015 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
2017 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Detailed adsorption mechanism of plasmid DNA by newly isolated cellulose from waste flower spikes of Thypa latifolia using quantum chemical calculations
2017 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Effect of different animal fat and plant oil additives on physicochemical, mechanical, antimicrobial and antioxidant properties of chitosan films
2018 ISSN: 0141-8130 SCI
Prof. Dr. İDRİS SARGIN →
Makale Bilgileri
ISSN01418130
Yayın TarihiAralık 2017
Cilt / Sayfa105 · 749-756
Scopus ID2-s2.0-85025159761
Özet
Sporopollenin is a promising material for drug encapsulation due to its excellent properties; uniformity in size, non-toxicity, chemically and thermally resilient nature. Herein, morphologically intact sporopollenin microcapsules were extracted from Betula pendula pollens. Cancer therapeutic agent (imatinib mesylate) was loaded into the microcapsules. The encapsulation efficiency by passive loading technique was found to be 21.46%. Release behaviour of the drug from microcapsules was found to be biphasic, with an initial fast release followed by a slower rate of release. Imatinib mesylate release from the drug itself (control) was faster than from imatinib mesylate-loaded sporopollenin microcapsules. The release profiles for both free and entrapped drug samples were significantly slower and more controlled in PBS buffer (pH 7.4) than in HCl (pH 1.2) buffer. Cumulative drug release from IM-MES-loaded sporopollenin microcapsules was found to be 65% within 24 h for PBS, whereas release from the control was completed within 1 h. Also, a complete dissolution of control in HCl buffer was observed within first 30 min. MTT assay revealed that drug-loaded microcapsules were effective on WiDr human colon carcinoma cell line. B. pendula sporopollenin can be suggested as an effective carrier for oral delivery of imatinib mesylate.
Yazarlar (9)
1
Idris Sargin
ORCID: 0000-0003-3785-9575
2
Lalehan Akyuz
3
Murat Kaya
4
G. Tan
5
Talip Ceter
6
Kevser Yildirim
7
Seymanur Ertosun
8
Gozde Hatun Aydin
9
Muge Topal
Anahtar Kelimeler
Encapsulation
Microcapsule
Oral drug delivery
Pollen
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Kastamonu University
Kastamonu Turkey
Scimago Dergi (ISSN Eşleşmesi)
International Journal of Biological Macromolecules
Q1
SJR Skoru1,287
H-Index247
YayıncıElsevier B.V.
ÜlkeNetherlands
Biochemistry (Q1)
Biomaterials (Q1)
Food Science (Q1)
Structural Biology (Q1)
Molecular Biology (Q2)
Metrikler
41
Atıf
9
Yazar
4
Anahtar Kelime