Scopus
YÖKSİS Eşleşti
Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications
Chemical Engineering Journal · Mart 2021
YÖKSİS Kayıtları
Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications
Chemical Engineering Journal · 2021 SCI-Expanded
PROFESÖR İDRİS SARGIN →
Makale Bilgileri
DergiChemical Engineering Journal
Yayın TarihiMart 2021
Cilt / Sayfa407
Scopus ID2-s2.0-85093930308
Özet
Porous, bioactive microspheres have always been a dream material to biomedical scientists for bone regeneration and drug delivery applications due to their interconnectivity, unique pore geometry, encapsulation ability and porosity spanning macroscopic, microscopic and nanoscopic length scales. Extensive efforts have been made to produce such materials synthetically at a great cost of money, time and labor. Herein, naturally-assembled multifunctional, open-channeled and hollow bioactive micro silica spheres (diameter 209.4 ± 38.5 µm) were discovered in a marine sponge (Geodia macandrewii), by peeling the outer surface of the sterrasters using hydrogen fluoride. The obtained micro silica spheres exhibited valuable characteristics such as homogeneously distributed pores, a cavity in the center of the sphere, and channels (approx. 3000) opening from each pore into the central cavity. Simulated body fluid analysis demonstrated the bioactivity of the micro silica spheres; whereas, no bioactivity was recorded for the original untreated sterrasters. The non-cytotoxicity and osteogenic ability of the isolated microspheres were confirmed through osteoblast cell culture. Finally, these silica based porous microspheres were tested for controlled drug release capacity. The spheres showed excellent loading and release abilities for an anti-cancer drug, carboplatin, in simulated solutions and in human cancer cell culture, HeLa, through a real time cell analyzer system. The drug loading capacity of the porous beads was determined as 10.59%. Considering the unique biological and physicochemical properties, these novel bioactive silica spheres, which we name as giant macroporous silica (GMS), are promising materials for a range of applications including bone tissue engineering and drug delivery.
Yazarlar (14)
1
Murat Kaya
2
Ismail Bilican
3
Muhammad Mujtaba
4
Idris Sargin
ORCID: 0000-0003-3785-9575
5
Merve Erginer Haskoylu
6
Ebru Toksoy Oner
7
Kai Zheng
8
Aldo R. Boccaccini
9
Demet Cansaran-Duman
10
M. Serdar Onses
11
Ilker Torun
12
Lalehan Akyuz
13
Caglar Elbuken
14
Martin Vinther Sørensen
Anahtar Kelimeler
Biosilica
Bone tissue
Drug release
Geodia
Macroporous silica
Porifera
Porous beads
Sterrasters
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Ankara Üniversitesi
Ankara Turkey
Bilkent Üniversitesi
Ankara Turkey
Erciyes Üniversitesi
Kayseri Turkey
Faculty of Medicine
Oulu Finland
Friedrich-Alexander-Universität Erlangen-Nürnberg
Erlangen Germany
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Statens Naturhistoriske Museum
Copenhagen Denmark
Metrikler
14
Atıf
14
Yazar
8
Anahtar Kelime