Scopus
YÖKSİS Eşleşti
The effect of levosimendan in rat mesenteric ischemia/reperfusion injury
Journal of Investigative Surgery · Aralık 2013
YÖKSİS Kayıtları
The Effect of Levosimendan in Rat Mesenteric Ischemia Reperfusion Injury
Journal of Investigative Surgery · 2013 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiJournal of Investigative Surgery
Yayın TarihiAralık 2013
Cilt / Sayfa26 · 325-333
Scopus ID2-s2.0-84887932975
Özet
Background: Intestinal ischemia reperfusion (IR) is associated with morbidity and mortality. We first examined the role of levosimendan in the protection of intestine after mesenteric IR. Methods: The rats were divided into six groups: (1) Control group; (2) Levosimendan group; (3) Ischemia group (60 min of occlusion); (4) IR group (60 min of occlusion and then 60 min reperfusion); (5) IR + 1 mg/kg levosimendan group: Levosimendan was given intraperitonally 30 min prior to the ischemia; (6) IR + 2 mg/kg levosimendan group. Results: The levels of TNF-α, IL-6, and IL-1β were found to have increased in the IR group. The serum levels of TNF-α, IL-6, and IL-1β were found to have decreased as a result of the administration of both doses of levosimendan in the IR. Relative TNF-α and NFκB mRNA levels was decreased by administration of both doses of levosimendan in the IR. SOD activity and GSH levels for IR group were lower than, and 8-ISO levels were higher than, those of the sham-operated rat and ischemia alone group. Conclusions: Both doses of levosimendan had preventive effects on the alterations that occurred in the intestinal tissues after IR. Levosimendan administration attenuated in reperfusion injury of intestine and consequently protects intestinal mucosa and oxidant-antioxidant balance of ileum. Copyright © 2013 Informa Healthcare USA, Inc.
Yazarlar (10)
1
Beyzagul Polat
2
Abdulmecit Albayrak
3
Zekai Halici
4
Emre Karakuş
5
Yasin Bayir
6
Elif Demirci
7
Elif Cadirci
8
Ersan Odaci
9
Muhammed Yayla
ORCID: 0000-0002-0659-3084
10
S. S. Atamanalp
Anahtar Kelimeler
Antioxidant
Cytokines
Ischemia-reperfusion
Levosimendan
Rat
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Karadeniz Technical University
Trabzon Turkey
Metrikler
12
Atıf
10
Yazar
5
Anahtar Kelime