Scopus
YÖKSİS Eşleşti
Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats
European Journal of Pharmacology · Mart 2014
YÖKSİS Kayıtları
Protective effect of Et 1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats
European Journal of Pharmacology · 2014 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiEuropean Journal of Pharmacology
Yayın TarihiMart 2014
Cilt / Sayfa726 · 87-95
Scopus ID2-s2.0-84893698707
Özet
Paracetamol is one of the first rank drugs which cause hepatic damage during drug intoxications. Endothelin (ET) which is known as one of the most potent vasoactive agent has been shown to contribute in the pathophysiology of various diseases. We hypothesized that bosentan, which is a non-selective ET-1 receptor antagonist, can prevent liver damage. This study included 49 female rats. Groups; I: Healthy group, II: Paracetamol (2 g/kg orally). Groups 3, 4 and 5 received NAC 140 mg/kg (2 doses), BOS 45 mg/kg and BOS 90 mg/kg orally, respectively. 1 h after administration of pretreatment drugs, Groups 3, 4, 5 were given paracetamol. VI: received BOS 90 mg/kg. VII: received 140 mg/kg NAC (2 doses). According to biochemical results, TNF-α, ALT and AST levels were statistically increased in the paracetamol group, these parameters were improved in the bosentan groups. Paracetamol administration decreased SOD activity, GSH level and increased level of MDA in the liver, while bosentan administration significantly improved these parameters. In immunohistochemical staining ET-1 receptor expression was excessively increased in paracetamol group, but not in bosentan groups when compared to healthy control. All these results suggest that bosentan exerted protective effects against experimentally induced paracetamol toxicity in liver. © 2014 Elsevier B.V.
Yazarlar (6)
1
Muhammed Yayla
ORCID: 0000-0002-0659-3084
2
Zekai Halici
3
Bunyami Unal
4
Yasin Bayir
5
Erol Akpinar
6
Fatma Gocer
Anahtar Kelimeler
Bosentan
ET-1
Hepatotoxicity
Paracetamol
Rat
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Metrikler
43
Atıf
6
Yazar
5
Anahtar Kelime