Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: Assessed with functional, molecular and electromicroscopic analyses
International Journal of Neuroscience · Aralık 2014
YÖKSİS Kayıtları
Protective effects of alpha lipoic acid on experimental sciatic nerve crush injury in rats assessed with functional molecular and electromicroscopic analyses
International Journal of Neuroscience · 2014 SCI-Expanded
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: assessed with functional, molecular and electromicroscopic analyses
International Journal of Neuroscience · 2014 SCI-Expanded
Prof. Dr. GÖKHAN ÖZDEMİR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Protective effects of alpha lipoic acid on experimental sciatic nerve crush injury in rats assessed with functional molecular and electromicroscopic analyses
2014 ISSN: 0020-7454 SCI-Expanded
Dr. Öğr. Üyesi MUHAMMED YAYLA →
CLINICAL IMPORTANCE OF ASYMMETRYAND HANDEDNESS DIFFERENCES IN COMMON CAROTID ARTERY INTIMA MEDIA THICKNESS
2007 ISSN: 0020-7454 SCI-Expanded 6 atıf
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Relationship between eye dominance and pattern electroretinograms innormal human subjects
2005 ISSN: 0020-7454 SSCI 3 atıf
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Investigation of the effect of telmisartan on experimentally induced peripheral nerve injury in rats
2014 ISSN: 0020-7454 SCI-Expanded
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EFFECT OF ACUTE SUBMAXIMAL EXERCISE ON INTRAOCULAR PRESSURE IN ATHLETES AND SEDENTARY SUBJECTS
2009 ISSN: 0020-7454 SCI-Expanded
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LONG-TERM EFFECTS OF MILD EXERCISE ON INTRAOCULAR PRESSURE IN ATHLETES AND SEDENTARY SUBJECTS
2009 ISSN: 0020-7454 SCI-Expanded
Dr. Öğr. Üyesi HAVVA DEMİREL →
Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: assessed with functional, molecular and electromicroscopic analyses
2014 ISSN: 0020-7454 SCI-Expanded
Prof. Dr. GÖKHAN ÖZDEMİR →
Sexual dependency of rat sciatic nerve fiber conduction velocity distributions
2007 ISSN: 0020-7454 SCI-Expanded
Prof. Dr. HÜLAGU BARIŞKANER →
The effect of bupivacaine on compound action potential parameters of sciatic nerve fibers
2004 ISSN: 0020-7454 SCI-Expanded
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Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
2020 ISSN: 0020-7454 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
2020 ISSN: 0020-7454 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
2020 ISSN: 0020-7454 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
Protective effects of nobiletin on cisplatin induced neurotoxicity in rats
2022 ISSN: 0020-7454 SCI-Expanded
Doç. Dr. MEHMET BURAK ATEŞ →
Protective effects of nobiletin on cisplatin induced neurotoxicity in rats
2022 ISSN: 0020-7454 Scopus, mmunology Abstracts; Journal Citation Reports/Science Edition; Medline/PubMed; Neuroscience Abstracts; Neuroscience Citation Index; PsychInfo; SciSearch; SCOPUS; Toxicology Abstracts, google scholar, sci
Prof. Dr. ÖZGÜR ÖZDEMİR →
The relationship of dog hippocampus to sex and paw preferance
2006 ISSN: 0020-7454 SCI
Prof. Dr. ENDER ERDOĞAN →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
2022 ISSN: 0020-7454 EBSCO, İndex Copernicus
Prof. Dr. ALİ ÜNLÜ →
Protective effects of nobiletin on cisplatin induced neurotoxicity in rats
2022 ISSN: 0020-7454 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
2022 ISSN: 0020-7454 Scopus
Prof. Dr. SEDAT ABUŞOĞLU →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
2022 ISSN: 0020-7454 SCI-Expanded Q4
Prof. Dr. ALİ ÜNLÜ →
Makale Bilgileri
ISSN00207454
Yayın TarihiAralık 2014
Cilt / Sayfa124 · 935-943
Scopus ID2-s2.0-84909943257
Özet
Aim: The present study aimed to demonstrate protective effects of alpha lipoic acid on experimental sciatic nerve crush injury model assessed with functional and electronmicroscopy analyses. Methods: In this study, groups were; Group 1; sham operated, Group 2; applied only sciatic nerve crush (Control), Group 3; Sciatic nerve crush + treated ALA 25 mg/kg (received orally) and Group 4; Sciatic nerve crush + treated ALA 50 mg/kg. Subsequently, sciatic nerves crush injury induced by forceps. At the second and fourth week, all animals were evaluated for sciatic functional index (SFI) and histomorphometric analyses with electronmicroscopy. Results: The SFI was significantly increased for both ALA-treated groups 30 days post-injury compared with control groups. The elecronmicroscopy results demonstrated that the axon diameter, the myelin diameter, the area of regenerating axon and miyelin were better in the treatment group than in the control group. Also ALA decreased IL-1β and Caspase 3 levels that increased in SNC group. Conclusions: These results suggest that ALA neuroprotective agent for peripheral nerve injury (PNI) and promoted peripheral nerve regeneration via its anti-inflammatory and antiapoptotic effects.
Yazarlar (8)
1
Recep Demir
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Erol Akpinar
4
Murtaza Cakir
5
Cagatay Calikoglu
6
Lutfu Ozel
7
Gokhan Ozdemir
ORCID: 0000-0001-8140-6333
8
Tolga Mercantepe
Anahtar Kelimeler
Alpha lipoic acid
Caspase 3
IL-1β
Nerve injury
Peripheral nerve
Rat
Sciatic nerve
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Palandoken Public Hospital
Yakutiye, Erzurum Turkey
Scimago Dergi (ISSN Eşleşmesi)
International Journal of Neuroscience
Q3
SJR Skoru0,506
H-Index85
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q3)
Neuroscience (miscellaneous) (Q3)
Metrikler
14
Atıf
8
Yazar
7
Anahtar Kelime