Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist
Basic and Clinical Pharmacology and Toxicology · Şubat 2016
YÖKSİS Kayıtları
The Role of Urotensin Receptors in the Paracetamol Induced Hepatotoxicity Model in Mice Ameliorative Potential of Urotensin II Antagonist
Basic Clinical Pharmacology Toxicology · 2016 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiBasic and Clinical Pharmacology and Toxicology
Yayın TarihiŞubat 2016
Cilt / Sayfa118 · 150-159
Scopus ID2-s2.0-84983143161
Erişim🔓 Açık Erişim
Özet
We aimed to evaluate the possible protective effect of a UTR antagonist and to determine the effect of the antagonist on ALT and AST levels in serum, the mRNA expression level of UTR, tumour necrosis factor-alpha (TNF-α) and IL-1β and SOD activity, GSH and MDA levels in liver tissues, which are important mediators or markers for the hepatotoxicity animal model in mice. Animals fasted overnight and were divided into seven equal groups (n = 12). The first group was the healthy group (administered 0.1% DMSO intraperitoneally). Group 2 received only paracetamol (PARA) (administered orally at a dosage of 300 mg/kg). Groups 3 and 4 were treated with only AGO (AC7954, UTR agonist) 15 and 30 mg/kg intraperitoneally, respectively. Groups 5 and 6 were treated with only ANTA (SB657510, UTR antagonist) 30 and 60 mg/kg intraperitoneally, respectively. Group 7 was treated with AGO 30 mg/kg and ANTA 60 mg/kg intraperitoneally. One hour after the pre-treatment drugs were administered, groups 3 through 7 were given PARA. After the experimental period, the mice were killed 6 and 24 hr after PARA was administered. Antagonist administration significantly decreased the ALT and AST levels, while agonist administration did not. In addition, SOD activity and GSH levels increased, and the MDA level decreased with the pre-treatment of two antagonist doses. The increased UTR gene expression through PARA was significantly lower in both doses of the antagonist groups at 24 hr when compared with the agonist and PARA groups. This study showed that UTR antagonists have hepatoprotective and anti-inflammatory effects on high-dose PARA-induced hepatotoxicity in mice.
Yazarlar (7)
1
Saziye Sezin Palabiyik
2
Emre Karakuş
3
Erol Akpinar
4
Zekai Halici
5
Yasin Bayir
6
Muhammed Yayla
ORCID: 0000-0002-0659-3084
7
Duygu Kose
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Metrikler
14
Atıf
7
Yazar