Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
A review of melatonin, its receptors and drugs
Eurasian Journal of Medicine · Haziran 2016
YÖKSİS Kayıtları
A Review of Melatonin, Its Receptors and Drugs
The Eurasian Journal of Medicine · 2016 ESCI
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiEurasian Journal of Medicine
Yayın TarihiHaziran 2016
Cilt / Sayfa48 · 135-141
Scopus ID2-s2.0-84979202523
Erişim🔓 Açık Erişim
Özet
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine. Melatonin, a hormone secreted from the pineal gland at night, plays roles in regulating sleep-wake cycle, pubertal development and seasonal adaptation. Melatonin has antinociceptive, antidepressant, anxiolytic, antineophobic, locomotor activityregulating, neuroprotective, anti-inflammatory, pain-modulating, blood pressure-reducing, retinal, vascular, anti-tumor and antioxidant effects. It is related with memory, ovarian physiology, and osteoblast differentiation. Pathologies associated with an increase or decrease in melatonin levels are summarized in the review. Melatonin affects by four mechanisms: 1) Binding to melatonin receptors in plasma membrane, 2) Binding to intracellular proteins such as calmoduline, 3) Binding to Orphan nuclear receptors, and 4) Antioxidant effect. Receptors associated with melatonin are as follows: 1) Melatonin receptor type 1a: MT1 (on cell membrane), 2) Melatonin receptor type 1b: MT2 (on cell membrane), 3) Melatonin receptor type 1c (found in fish, amphibians and birds), 4) Quinone reductase 2 enzyme (MT3 receptor, a detoxification enzyme), 5) RZR/RORα: Retinoid-related Orphan nuclear hormone receptor (with this receptor, melatonin binds to the transcription factors in nucleus), and 6) GPR50: X-linked Melatonin-related Orphan receptor (it is effective in binding of melatonin to MT1). Melatonin agonists such as ramelteon, agomelatine, circadin, TIK-301 and tasimelteon are introduced and side effects will be discussed. In conclusion, melatonin and related drugs is a new and promising era for medicine. Melatonin receptors and melatonin drugs will take attention with greater interest day by day in the future.
Yazarlar (6)
1
Mucahit Emet
2
Halil Ozcan
3
Lutfu Ozel
4
Muhammed Yayla
ORCID: 0000-0002-0659-3084
5
Zekai Halici
6
Ahmet Hacımuftuoglu
Anahtar Kelimeler
Agonists
Melatonin
Pineal gland
Receptors
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Metrikler
214
Atıf
6
Yazar
4
Anahtar Kelime