Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
A review of melatonin, its receptors and drugs
Eurasian Journal of Medicine · Haziran 2016
YÖKSİS Kayıtları
A Review of Melatonin, Its Receptors and Drugs
The Eurasian Journal of Medicine · 2016 ESCI
Dr. Öğr. Üyesi MUHAMMED YAYLA →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Multiple Intestinal Perforation and Necrosis due to Magnet Ingestion
2016 ISSN: 13088734 ESCI
Prof. Dr. İLHAN ÇİFTCİ →
Multiple Intestinal Perforation and Necrosis due to Magnet Ingestion
2016 ISSN: 13088734 ESCI
Prof. Dr. TAMER SEKMENLİ →
Primary Pleomorphic Rhabdomyosarcoma of Thyroid Gland in an Adult Patient A Case Report
2016 ISSN: 13088734 ESCI
Prof. Dr. SÜLEYMAN BALDANE →
A Review of Melatonin, Its Receptors and Drugs
2016 ISSN: 13088734 ESCI
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Frequency and Significance of Perforating Venous Insufficiency in Patients with Chronic Venous Insufficiency of Lower Extremity
2018 ISSN: 13088734 Art Index (Art Research Database, EBSCO)
Prof. Dr. MEHMET SEDAT DURMAZ →
Prevalence of Tension-Type Headache in Individuals Aged between 18-65 Years in the Eastern Parts of Turkey
2014 ISSN: 13088734 TR DİZİN
Prof. Dr. GÖKHAN ÖZDEMİR →
Wide Central Pontine, Bulbar and Thalamic Myelinolysis with Sequela
2012 ISSN: 13088734 TR DİZİN
Prof. Dr. GÖKHAN ÖZDEMİR →
Unilateral Nasal Obstruction Caused by a Large Nasopharyngeal Cyst
2018 ISSN: 13088734 PubMed Central, Emerging Sources Citation Index (ESCI), Index Copernicus, EBSCO, Gale/Cengage, CINAHL, ProQuest, ULAKBIM/Turkish Medical Index, Turkiye Citation Index
Doç. Dr. NURDOĞAN ATA →
Cystic Lung Disease in Birt-Hogg-Dubé Syndrome: A Case Series of Three Patients
2014 ISSN: 1308-8734 TR DİZİN
Doç. Dr. ABİDİN KILINÇER →
Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model
2019 ISSN: 1308-8734 ESCI
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Superb Microvascular Imaging at Evaluation of Nonvisible Buried De-epitelized flap vascularization in Breast Reconstruction.
2023 ISSN: 1308-8734 Emerging Sources Citation Index (ESCI), DOAJ, Scopuss
Doç. Dr. EMİNE UYSAL →
Makale Bilgileri
ISSN13088734
Yayın TarihiHaziran 2016
Cilt / Sayfa48 · 135-141
Scopus ID2-s2.0-84979202523
Erişim🔓 Açık Erişim
Özet
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine. Melatonin, a hormone secreted from the pineal gland at night, plays roles in regulating sleep-wake cycle, pubertal development and seasonal adaptation. Melatonin has antinociceptive, antidepressant, anxiolytic, antineophobic, locomotor activityregulating, neuroprotective, anti-inflammatory, pain-modulating, blood pressure-reducing, retinal, vascular, anti-tumor and antioxidant effects. It is related with memory, ovarian physiology, and osteoblast differentiation. Pathologies associated with an increase or decrease in melatonin levels are summarized in the review. Melatonin affects by four mechanisms: 1) Binding to melatonin receptors in plasma membrane, 2) Binding to intracellular proteins such as calmoduline, 3) Binding to Orphan nuclear receptors, and 4) Antioxidant effect. Receptors associated with melatonin are as follows: 1) Melatonin receptor type 1a: MT1 (on cell membrane), 2) Melatonin receptor type 1b: MT2 (on cell membrane), 3) Melatonin receptor type 1c (found in fish, amphibians and birds), 4) Quinone reductase 2 enzyme (MT3 receptor, a detoxification enzyme), 5) RZR/RORα: Retinoid-related Orphan nuclear hormone receptor (with this receptor, melatonin binds to the transcription factors in nucleus), and 6) GPR50: X-linked Melatonin-related Orphan receptor (it is effective in binding of melatonin to MT1). Melatonin agonists such as ramelteon, agomelatine, circadin, TIK-301 and tasimelteon are introduced and side effects will be discussed. In conclusion, melatonin and related drugs is a new and promising era for medicine. Melatonin receptors and melatonin drugs will take attention with greater interest day by day in the future.
Yazarlar (6)
1
Mucahit Emet
2
Halil Ozcan
3
Lutfu Ozel
4
Muhammed Yayla
ORCID: 0000-0002-0659-3084
5
Zekai Halici
6
Ahmet Hacımuftuoglu
Anahtar Kelimeler
Agonists
Melatonin
Pineal gland
Receptors
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
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Scimago Dergi (ISSN Eşleşmesi)
Eurasian Journal of Medicine
Q3
OA
SJR Skoru0,344
H-Index26
YayıncıAVES
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Metrikler
261
Atıf
6
Yazar
4
Anahtar Kelime