Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media
Journal of Laryngology and Otology · Temmuz 2016
YÖKSİS Kayıtları
Anti inflammatory and anti oxidative effects of alpha lipoic acid in experimentally induced acute otitis media
The Journal of Laryngology Otology · 2016 SCI-Expanded
Dr. Öğr. Üyesi MUHAMMED YAYLA →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Association of age related macular degeneration with age related hearing loss
2011 ISSN: 0022-2151 SCI-Expanded
Prof. Dr. BANU TURĞUT ÖZTÜRK →
Association of age related macular degeneration with age related hearing loss
2011 ISSN: 0022-2151 SCI-Expanded
Prof. Dr. BANU TURĞUT ÖZTÜRK →
Association of age related macular degeneration with age related hearing loss
2011 ISSN: 0022-2151 SCI-Expanded
Prof. Dr. BANU TURĞUT ÖZTÜRK →
Anti inflammatory and anti oxidative effects of alpha lipoic acid in experimentally induced acute otitis media
2016 ISSN: 0022-2151 SCI-Expanded
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Association of age related macular degeneration with age related hearing loss
2011 ISSN: 0022-2151 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus
2018 ISSN: 0022-2151 SCI-Expanded Q4
Prof. Dr. BÜLENT ULUSOY →
Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections
2016 ISSN: 0022-2151 SCI-Expanded
Doç. Dr. NURDOĞAN ATA →
Effects of primary Sjögren's syndrome on hearing and vestibular systems
2022 ISSN: 0022-2151 SCI-Expanded Q3
Prof. Dr. BÜLENT ULUSOY →
Effects of Primary Sjogren Syndrome on Hearing and Vestibuler Systems
2022 ISSN: 0022-2151 SCI-Expanded
Prof. Dr. SEMA YILMAZ →
Effects of primary Sjogren's syndrome on hearing and vestibular systems
2022 ISSN: 0022-2151 SCI-Expanded Q3
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Association of age related macular degeneration with age related hearing loss
2011 ISSN: 0022-2151 SCI
Prof. Dr. BANU BOZKURT →
Makale Bilgileri
ISSN00222151
Yayın TarihiTemmuz 2016
Cilt / Sayfa130 · 616-623
Scopus ID2-s2.0-84971433409
Özet
Objectives: To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media. Methods: Twenty-five Guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid plus penicillin G. Tissue samples were histologically analysed, and oxidative parameters in tissue samples were measured and compared between groups. Results: The epithelial integrity was better preserved, and histological signs of inflammation and secretory metaplasia were decreased, in all groups compared to the saline treated otitis group. In the alpha-lipoic acid plus penicillin G treated otitis group, epithelial integrity was well preserved and histological findings of inflammation were significantly decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group. Conclusion: Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media.
Yazarlar (9)
1
Arzu Tatar
2
Mukadder Korkmaz
3
Muhammed Yayla
ORCID: 0000-0002-0659-3084
4
Mustafa Sitki Gozeler
5
Vahit Mutlu
ORCID: 0000-0002-2803-3328
6
Zekai Halici
7
Hakan Uslu
8
H. Korkmaz
9
J. Selli
Anahtar Kelimeler
Alpha-Lipoic Acid
Guinea Pig
Inflammation
Otitis Media
Reactive Oxygen Species
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Ordu Üniversitesi
Ordu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Laryngology and Otology
Q3
SJR Skoru0,423
H-Index79
YayıncıCambridge University Press
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q3)
Otorhinolaryngology (Q3)
Metrikler
5
Atıf
9
Yazar
5
Anahtar Kelime