Scopus
YÖKSİS Eşleşti
Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats
Peptides · Ağustos 2016
YÖKSİS Kayıtları
Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats
Peptides · 2016 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiPeptides
Yayın TarihiAğustos 2016
Cilt / Sayfa82 · 35-43
Scopus ID2-s2.0-84973299448
Özet
This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20 mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30 mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30 mg/kg. 1 h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-α and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation.
Yazarlar (9)
1
Elif Cadirci
2
Zekai Halici
3
Muhammed Yayla
ORCID: 0000-0002-0659-3084
4
Erdem Toktay
ORCID: 0000-0002-0715-2707
5
Yasin Bayir
6
Emre Karakuş
7
Atilla Topcu
8
Basak Buyuk
9
Abdulmecit Albayrak
Anahtar Kelimeler
Inflammation
Rats
SB657510
TNF-Alpha
Urotensin II
Kurumlar
19 Mart University
Canakkale Turkey
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Faculty of Medicine
Rize Turkey
Kafkas Üniversitesi
Kars Turkey
Metrikler
20
Atıf
9
Yazar
5
Anahtar Kelime