Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: The protective potential of epigallocatechin-3-gallate
Renal Failure · Ocak 2017
YÖKSİS Kayıtları
A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: the protective potential of epigallocatechin-3-gallate
Renal Failure · 2017 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiRenal Failure
Yayın TarihiOcak 2017
Cilt / Sayfa39 · 314-322
Scopus ID2-s2.0-85016126121
Erişim🔓 Açık Erişim
Özet
Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its mechanisms of protection against toxicity, using models of GLY and CIN in rats. The rats were separated into eight groups (n=6 in each), as follows: Healthy, GLY, CM, GLY+CM, CM+EGCG 50mg/kg (po), GLY+CM+EGCG 50mg/kg (po), CM+EGCG 100mg/kg (po), and GLY+CM+EGCG 100mg/kg (po). Both doses of EGCG protected against CM-induced renal dysfunction, as measured by serum creatinine and blood urea nitrogen (BUN). In addition, EGCG treatment markedly improved CIN-induced oxidative stress, and resulted in a significant down-regulatory effect on tumor necrosis factor (TNF)-α and nuclear factor (NF)-κB mRNA expression. Moreover, histopathological analysis showed that EGCG also attenuated CM-induced kidney damage. Considering the potential clinical use of CM and the numerous health benefits of EGCG, this study showed the protective role of multi-dose EGCG treatment on CIN and GLY-aggravated CIN through different mechanisms.
Yazarlar (8)
1
Saziye Sezin Palabiyik
2
Busra Dincer
ORCID: 0000-0002-3365-7741
3
Elif Cadirci
4
Irfan Cinar
ORCID: 0000-0002-9826-2556
5
Cemal Gundogdu
6
Beyzagul Polat
7
Muhammed Yayla
ORCID: 0000-0002-0659-3084
8
Zekai Halici
Anahtar Kelimeler
Contrast media
EGCG
Nephrotoxicity
Rat
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kafkas Üniversitesi
Kars Turkey
Metrikler
17
Atıf
8
Yazar
4
Anahtar Kelime