Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The potential role of amlodipine on experimentally induced bacterial rhinosinusitis
Brazilian Journal of Otorhinolaryngology · Kasım 2017
YÖKSİS Kayıtları
The potential role of amlodipine on experimentally induced bacterial rhinosinusitis
Brazilian Journal of Otorhinolaryngology · 2017 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiBrazilian Journal of Otorhinolaryngology
Yayın TarihiKasım 2017
Cilt / Sayfa83 · 619-626
Scopus ID2-s2.0-85005978265
Erişim🔓 Açık Erişim
Özet
Introduction Antibiotics are frequently used for the treatment of rhinosinusitis. Concerns have been raised regarding the adverse effects of antibiotics and growing resistance. The lack of development of new antibiotic compounds has increased the necessity for exploration of non-antibiotic compounds that have antibacterial activity. Amlodipine is a non-antibiotic compound with anti-inflammatory activity. Objective In this study we aimed to investigate the potential role of amlodipine in the treatment of rhinosinusitis by evaluating its effects on tissue oxidative status, mucosal histology and inflammation. Methods Fifteen adult albino guinea pigs were inoculated with Staphylococcus aureus and treated with saline, cefazolin sodium, or amlodipine for 7 days. The control group was composed by five healthy guinea pigs. Animals were sacrificed after the treatment. Histopathological changes were identified using Hematoxylin-Eosin staining. Inflammation was assessed by Polymorphonuclear Leukocyte infiltration density. Tissue levels of antioxidants (superoxide dismutase, glutathione) and an oxidative product (malondialdehyde) were determined. Results In rhinosinusitis induced animals, amlodipine reduced loss of cilia, lamina propria edema and collagen deposition compared to placebo (saline) and although not superior to cefazolin, amlodipine decreased polymorphonuclear leukocyte infiltration. The superoxide dismutase activity and glutathione levels were reduced, whereas the malondialdehyde levels were increased significantly in all three-treatment groups compared to the control group. Amlodipine treated group showed significantly increased superoxide dismutase and glutathione levels and decreased malondialdehyde levels compared to all treatment groups. Conclusion The non-antibiotic compound amlodipine may have a role in acute rhinosinusitis treatment through tissue protective, antioxidant and anti-inflammatory mechanisms.
Yazarlar (7)
1
Arzu Tatar
2
Mukadder Korkmaz
3
Muhammed Yayla
ORCID: 0000-0002-0659-3084
4
Elif Polat
5
Hakan Uslu
6
Zekai Halici
7
Secil N. Parlak
Anahtar Kelimeler
Amlodipine
Antioxidants
Guinea pig
Non-antibiotic
Rhinosinusitis
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Kafkas Üniversitesi
Kars Turkey
Ordu Üniversitesi
Ordu Turkey
Metrikler
5
Atıf
7
Yazar
5
Anahtar Kelime