Scopus
YÖKSİS Eşleşti
Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats
Iranian Journal of Basic Medical Sciences · Aralık 2018
YÖKSİS Kayıtları
Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats
The Iranian Journal of Basic Medical Sciences · 2018 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiIranian Journal of Basic Medical Sciences
Yayın TarihiAralık 2018
Cilt / Sayfa21 · 1262-1268
Scopus ID2-s2.0-85055647502
Özet
Objective(s): The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Materials and Methods: Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0,32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0.64 ml / kg, Group 6; Ischemia + Pomegranate 0,32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0,64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated. Results: While NADPH oxidase activity, MDA and TNF-α levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose pomegranate seed oil application reduced significantly oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose pomegranate seed oil extract reduced TNF-α levels and significantly increased antioxidant activity. Conclusion: PSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury.
Yazarlar (5)
1
Muhammed Yayla
ORCID: 0000-0002-0659-3084
2
D. Cetin
3
Yasemen Adali
4
Pinar Aksu Kilicle
ORCID: 0000-0002-3567-5775
5
Erdem Toktay
ORCID: 0000-0002-0715-2707
Anahtar Kelimeler
Ischemia/reperfusion
Ovary
Oxidative stress
Pomegranate seed oil
Punicaceae
Rats
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Çanakkale Onsekiz Mart Üniversitesi
Canakkale Turkey
Kafkas Üniversitesi
Kars Turkey
Metrikler
18
Atıf
5
Yazar
6
Anahtar Kelime