Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effect of prostaglandin e1 analog misoprostol in an ovalbumin-induced allergic rhinitis model
Eurasian Journal of Medicine · Şubat 2019
YÖKSİS Kayıtları
Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model
The Eurasian Journal of Medicine · 2019 ESCI
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiEurasian Journal of Medicine
Yayın TarihiŞubat 2019
Cilt / Sayfa51 · 75-79
Scopus ID2-s2.0-85063493105
Erişim🔓 Açık Erişim
Özet
Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group. Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups. Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.
Yazarlar (10)
1
Zülküf Kaya
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Arzu Bilen
4
Nihal Efe Atilla
ORCID: 0000-0002-3239-4142
5
Sevilay Ozmen
6
Irfan Cinar
ORCID: 0000-0002-9826-2556
7
Zafer Bayraktutan
8
Vahit Mutlu
ORCID: 0000-0002-2803-3328
9
Harun Un
ORCID: 0000-0003-1772-282X
10
Erdem Toktay
ORCID: 0000-0002-0715-2707
Anahtar Kelimeler
Allergy
Desloratadine
Misoprostol
Rat
Rhinitis
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzurum Training and Research Hospital
Erzurum Turkey
Kafkas Üniversitesi
Kars Turkey
Metrikler
2
Atıf
10
Yazar
5
Anahtar Kelime