Scopus
YÖKSİS Eşleşti
Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression
International Journal of Biological Macromolecules · Kasım 2021
YÖKSİS Kayıtları
Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression
International Journal of Biological Macromolecules · 2021 SCI
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiInternational Journal of Biological Macromolecules
Yayın TarihiKasım 2021
Cilt / Sayfa190 · 911-918
Scopus ID2-s2.0-85114951808
Özet
This study aimed to investigate the effects of blood glucose control and the kidneys' functions, depending on fasting, in the streptozotocin-induced diabetes model in rats via TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression in the present study. 32 Wistar albino rats were allocated randomly into four main groups; H (Healthy, n = 6), HF (Healthy fasting, n = 6), D (Diabetes, n = 10), DF (Diabetes and fasting, n = 10). Blood glucose and HbA1c levels significantly increased in the D group compared to the healthy ones (p < 0.05). However, the fasting period significantly improved blood glucose and HbA1c levels 14 days after STZ induced diabetes in rats compared to the D group. Similar findings we obtained for serum (BUN-creatinine) and urine samples (creatinine and urea levels). STZ induced high glucose levels significantly up-regulated TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression and fasting significantly decreased these parameters when compared to diabetic rats. Histopathological staining also demonstrated the protective effects of fasting on diabetic kidney tissue. In conclusion, intermittent fasting regulated blood glucose level as well as decreasing harmful effects of diabetes on kidney tissue. The fasting period significantly decreased the hyperglycemia-related inflammatory cytokine damage on kidneys and also reduced apoptosis in favor of living organisms.
Yazarlar (10)
1
Arzu Bilen
2
Ilknur Calik
3
Muhammed Yayla
ORCID: 0000-0002-0659-3084
4
Busra Dincer
ORCID: 0000-0002-3365-7741
5
Taha Tavaci
6
Irfan Cinar
ORCID: 0000-0002-9826-2556
7
Habip Bilen
8
Elif Cadirci
9
Zekai Halici
10
Filiz Mercantepe
Anahtar Kelimeler
Diabetes
Fasting
Kidney
Rat
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Kafkas Üniversitesi
Kars Turkey
Kastamonu University
Kastamonu Turkey
Metrikler
12
Atıf
10
Yazar
4
Anahtar Kelime