Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Does the cardiovascular drug levosimendan prevent iodinated contrast medium nephrotoxicity with glycerol aggravation in rats?
European Radiology Experimental · Aralık 2021
YÖKSİS Kayıtları
Does the cardiovascular drug levosimendan prevent iodinated contrast medium nephrotoxicity with glycerol aggravation in rats?
European Radiology Experimental · 2021 ESCI
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiEuropean Radiology Experimental
Yayın TarihiAralık 2021
Cilt / Sayfa5
Scopus ID2-s2.0-85119116485
Erişim🔓 Açık Erişim
Özet
Background: We investigated whether levosimendan prevents contrast medium nephrotoxicity with glycerol aggravation in rats. Methods: Forty-eight Wistar albino rats were assigned to eight groups (n = 6 × 8). No medication was administered to group I (controls); glycerol (intramuscular injection of 25% glycerol, 10 mL/kg) group II; intravenous iohexol 10 mL/kg to group III; glycerol and iohexol to group IV; iohexol and intraperitoneal levosimendan 0.25 mg/kg to group V; glycerol, iohexol, and levosimendan 0.25 mg/kg to group VI; iohexol and levosimendan 0.5 mg/kg to group VII; and glycerol, iohexol, and levosimendan 0.5 mg/kg to group VIII. One-day water withdrawal and glycerol injection prompted renal damage; iohexol encouraged nephrotoxicity; levosimendan was administered 30 min after glycerol injection and continued on days 2, 3, and 4. The experiment was completed on day 5. Serum blood urea nitrogen (BUN) and creatinine levels, superoxide dismutase (SOD) activity, glutathione (GSH), malondialdehyde (MDA) levels, tumour necrosis factor-α (TNF-α), nuclear factor kappa ß (NFK-ß), interleukin 6 (IL-6), and histopathological marks were assessed. One-way analysis of variance and Duncan’s multiple comparison tests were used. Results: Levosimendan changed serum BUN (p = 0.012) and creatinine (p = 0.018), SOD (p = 0.026), GSH (p = 0.012), and MDA (p = 0.011). Levosimendan significantly downregulated TNF-α (p = 0.022), NFK-ß (p = 0.008), and IL-6 (p = 0.033). Histopathological marks of hyaline and haemorrhagic cast were improved in levosimendan-injected groups. Conclusion: Levosimendan showed nephroprotective properties due to its vasodilator, oxidative distress decreasing and inflammatory cytokine preventing belongings.
Yazarlar (7)
1
Irmak Durur-Subasi
ORCID: 0000-0003-3122-4499
2
Duygu Kose
3
Muhammed Yayla
ORCID: 0000-0002-0659-3084
4
Busra Sirin
5
Adem Karaman
6
Ilknur Calik
7
Fatih Alper
Anahtar Kelimeler
Contrast media
Drug-related side effects and adverse reactions
Iohexol
Levosimendan
Rats (Wistar)
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
İstanbul Medipol Üniversitesi
Istanbul Turkey
Kafkas Üniversitesi
Kars Turkey