Scopus
YÖKSİS Eşleşti
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
Molecular Biology Reports · Mayıs 2022
YÖKSİS Kayıtları
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
Springer Science and Business Media LLC · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiMolecular Biology Reports
Yayın TarihiMayıs 2022
Cilt / Sayfa49 · 3875-3883
Scopus ID2-s2.0-85126460468
Özet
Aim: We aimed to investigate the effects of rasagiline on acute lung injury that develops in the sepsis model induced with the cecal ligation and puncture in rats. Main Methods: The rats were separated into the following six groups, Group 1: Sham, Group 2: Sham + Rasagiline 4 mg/kg, Group 3: Sepsis, Group 4: Sepsis + Rasagiline 1 mg/kg, Group 5: Sepsis + Rasagiline 2 mg/kg, Group 6: Sepsis + Rasagiline 4 mg/kg. A total of four holes were opened with a 16-gauge needle through the cecum distal to the point of ligation. Key Findings: Rasagiline treatment increased glutathione level and superoxide dismutase activity while decreased the malondialdehyde level after the sepsis. There was a statistically significant improvement in the doses of 2 mg/kg and 4 mg/kg. Rasagiline also increased Tnf-α, IL1β, IL6, NF-κβand HMGB1 gene expressions in dose-dependent at 2 mg/kg and 4 mg/kg doses. In increased doses, rasagiline prevent the development of edema, the formation of inflammation, and hemorrhage. Significance: Rasagiline exerts both antioxidant and anti-inflammatory effects on the cecal ligation and puncture induced acute lung injury in rats.
Yazarlar (7)
1
Harun Un
ORCID: 0000-0003-1772-282X
2
Rustem Anil Ugan
ORCID: 0000-0002-4837-2343
3
Duygu Kose
4
Muhammed Yayla
ORCID: 0000-0002-0659-3084
5
Tugba Bal Tastan
6
Yasin Bayir
7
Zekai Halici
Anahtar Kelimeler
Cecal ligation and puncture
Inflammation
Rasagiline
Rat
Sepsis
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kafkas Üniversitesi
Kars Turkey
Metrikler
8
Atıf
7
Yazar
5
Anahtar Kelime