Scopus
YÖKSİS DOI Eşleşti
SJR Q2
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
Molecular Biology Reports · Mayıs 2022
YÖKSİS Kayıtları
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
Springer Science and Business Media LLC · 2022 SCI-Expanded
Dr. Öğr. Üyesi MUHAMMED YAYLA →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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Glutathione S-transferase M1 and T1 genotypes and myocardial infarction
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In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium
2019 ISSN: 0301-4851 SCI
Prof. Dr. NURANİYE ERUYGUR →
NF‑ĸβ upregulates ADAMTS5 expression by direct binding after TNF‑α
treatment in OUMS‑27 chondrosarcoma cell line 2020 Jun;47(6):4215-4223
2020 ISSN: 0301-4851 SSCI
Prof. Dr. TÜLÜN ÇORA →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
Arş. Gör. FATMA GÖKTÜRK →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. MERİH ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge
between circadian rhythm and glucose metabolism, in a Turkish
population
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
2022 ISSN: 0301-4851 SCI-Expanded Q4
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Glutathione S transferase M1 and T1 genotypes and myocardial infarction
2013 ISSN: 0301-4851 SCI
Prof. Dr. HASAN ACAR →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. BAHADIR ÖZTÜRK →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi DUYGU DURSUNOĞLU →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. ESMA MENEVŞE →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation of the effects of gabapentin on high glucose-induced neurotoxicity and genotoxicity in an in vitro model of diabetic neuropathy and in silico molecular docking analysis
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi BATUHAN BİLGİN →
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Makale Bilgileri
ISSN03014851
Yayın TarihiMayıs 2022
Cilt / Sayfa49 · 3875-3883
Scopus ID2-s2.0-85126460468
Özet
Aim: We aimed to investigate the effects of rasagiline on acute lung injury that develops in the sepsis model induced with the cecal ligation and puncture in rats. Main Methods: The rats were separated into the following six groups, Group 1: Sham, Group 2: Sham + Rasagiline 4 mg/kg, Group 3: Sepsis, Group 4: Sepsis + Rasagiline 1 mg/kg, Group 5: Sepsis + Rasagiline 2 mg/kg, Group 6: Sepsis + Rasagiline 4 mg/kg. A total of four holes were opened with a 16-gauge needle through the cecum distal to the point of ligation. Key Findings: Rasagiline treatment increased glutathione level and superoxide dismutase activity while decreased the malondialdehyde level after the sepsis. There was a statistically significant improvement in the doses of 2 mg/kg and 4 mg/kg. Rasagiline also increased Tnf-α, IL1β, IL6, NF-κβand HMGB1 gene expressions in dose-dependent at 2 mg/kg and 4 mg/kg doses. In increased doses, rasagiline prevent the development of edema, the formation of inflammation, and hemorrhage. Significance: Rasagiline exerts both antioxidant and anti-inflammatory effects on the cecal ligation and puncture induced acute lung injury in rats.
Yazarlar (7)
1
Harun Un
ORCID: 0000-0003-1772-282X
2
Rustem Anil Ugan
ORCID: 0000-0002-4837-2343
3
Duygu Kose
4
Muhammed Yayla
ORCID: 0000-0002-0659-3084
5
Tugba Bal Tastan
6
Yasin Bayir
7
Zekai Halici
Anahtar Kelimeler
Cecal ligation and puncture
Inflammation
Rasagiline
Rat
Sepsis
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kafkas Üniversitesi
Kars Turkey
Scimago Dergi (ISSN Eşleşmesi)
Molecular Biology Reports
Q2
SJR Skoru0,743
H-Index103
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Genetics (Q2)
Medicine (miscellaneous) (Q2)
Molecular Biology (Q3)
Metrikler
10
Atıf
7
Yazar
5
Anahtar Kelime