Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin-induced stomach ulcer in rats
Journal of Food Biochemistry · Eylül 2022
YÖKSİS Kayıtları
The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin‐induced stomach ulcer in rats
Journal of Food Biochemistry · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiJournal of Food Biochemistry
Yayın TarihiEylül 2022
Cilt / Sayfa46
Scopus ID2-s2.0-85132044435
Erişim🔓 Açık Erişim
Özet
The aim of this study was to investigate the effects of red dragon fruit (Hylocereus polyrhizus) extract (DFE) on the stomach in ulcer model induced by indomethacin in rats. Effects of DFE were evaluated in indomethacin-induced gastric damage model on Sprague–Dawley rats. Experimental model: all rats were fasted for 24 h. At the end of this period, DFE was administered to the ulcer-induced groups. One hour after this application, a dose of 25 mg/kg of indomethacin was applied by oral gavage to all groups except the HEALTHY and DFE1000 groups. Six hours after indomethacin administration, the rats were euthanized with high-dose anesthesia and the experiment was terminated. Macroscopic and microscopic analyses for investigating ulcerative area, molecular and biochemical analyses for oxidative damages investigation and molecular analyses for the effect mechanism of indomethacin and DFE were conducted on stomach tissues in the study. While oxidative stress-associated markers such as MDA, BAX, and Caspase 3 increased dramatically in the indomethacin group, GSH antioxidant levels decreased. It was observed that these parameters were significantly improved in DFE 500 mg/kg and DFE 1000 mg/kg groups compared to ulcer group, and the results of especially DFE 1000 mg/kg group were similar to famotidine group. We observed that our histopathological findings also supported all our other findings. Dragon fruit extract was protected against indomethacin-induced ulcer damage by decreased MDA levels, increased GSH levels, and inhibition of Caspase 3, BAX, and Cox-2, and activation of Cox-1. Practical applications: People of all ages around the world suffer from gastric ulcer which is one of the most common gastrointestinal ailments. The etiological factors of the disease are using of cigarette and alcohol, nutritional deficiencies, infections, and using non-steroidal anti-inflammatory drugs which use frequent and indiscriminate. Indomethacin is one of the NSAIDs and is commonly preferred to induce ulcer modeling in rats due to its gastric toxicity potential. Current anti-ulcer drugs have many serious side effects. Patients who suffered from gastric ulcer tend to discontinue the drug because of side effects. Therefore, patients need new agents that are non-toxic, have few side effects, and are easily accessible anti-ulcer drugs. Dragon fruit, as a medicinal herb, is highly valuable and widely used in traditional medicine, and may provide gastroprotective activity. Studies have shown that H. polyrhizus has antioxidant activities. We consider the effects of dragon fruit extract (DFE) to be a therapeutic drug for an indomethacin-induced ulcer model.
Yazarlar (10)
1
Erdem Toktay
ORCID: 0000-0002-0715-2707
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Levent Sahin
ORCID: 0000-0003-0193-4393
4
Ahmet Harmankaya
ORCID: 0000-0001-9923-6723
5
Cem Öziç
ORCID: 0000-0001-5415-9277
6
Pinar Aksu Kilicle
ORCID: 0000-0002-3567-5775
7
Muhammet Ali Gurbuz
ORCID: 0000-0001-8750-2393
8
Elif Erbas
ORCID: 0000-0003-1750-3889
9
Ozlem Demir
ORCID: 0000-0001-9852-8839
10
Pinar Bayram
ORCID: 0000-0001-9924-7051
Anahtar Kelimeler
rat
red dragon fruit
stomach
ulcer
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kafkas Üniversitesi
Kars Turkey
Metrikler
9
Atıf
10
Yazar
4
Anahtar Kelime