Scopus
YÖKSİS DOI Eşleşti
SJR Q3
In vitro Evaluation of the Effects of Inula viscosa's Different Extracts on Wound Healing and Oxidative Stress in Mouse L929 Fibroblast Cell Line
Fabad Journal of Pharmaceutical Sciences · Mart 2024
YÖKSİS Kayıtları
In vitro Evaluation of the Effects of Inula viscosa’s Different Extracts on Wound Healing and Oxidative Stress in Mouse L929 Fibroblast Cell Line
Fabad Journal of Pharmaceutical Sciences · 2024 scopus
Dr. Öğr. Üyesi MUHAMMED YAYLA →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Intranasal Delivery of Nicotine Via Thermoresponsive Hydrogel Systems: Design, Characterization, And In Vitro Evaluation
2026 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
2023 ISSN: 1300-4182 SCOPUS
Prof. Dr. SALİH MAÇİN →
In vitro Evaluation of the Effects of Inula viscosa’s Different Extracts on Wound Healing and Oxidative Stress in Mouse L929 Fibroblast Cell Line
2024 ISSN: 1300-4182 scopus
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
2025 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
2025 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Makale Bilgileri
ISSN13004182
Yayın TarihiMart 2024
Cilt / Sayfa49 · 129-142
Scopus ID2-s2.0-85188995769
Özet
This study evaluated the effects of extracts prepared using two different methods (decoction extraction and soxhlet ethyl acetate/hexane extraction) from Inula viscosa on H2O2-induced oxidative stress and wound healing model in mouse L929 fibroblast cells. The cytotoxic effect started to disappear statistically (p<0.05) at concentrations of Soxhlet ethyl acetate/hexane extracts (SoxEHE) in and below 0.1 mg/ mL, while the same effect was observed at concentrations of decoction extracts (DE) in and below 0.2 mg/mL. Therefore, 0.2 and 0.02 mg/ mL concentrations of DE, and 0.1 and 0.01 mg/mL concentrations of SoxEHEs were used. While cell migration was positively affected in all research concentrations, statistically significant results (p<0.05) were obtained from 0.2 mg/mL of DE and 0.1 mg/mL of SoxEHE extracts. Malondialdehyde (MDA) levels were found to be statistically (p <0.05) decreased, but COL1A1 levels were higher in cell lines treated with oxidative stress + extract than in the cell line treated only with H2O2, and reduced glutathione (GSH) levels were higher in cell lines only treated only with extract than in oxidative stress-induced cell lines. Consequently, it has been observed that the extracts have positive effects on migration and oxidative stress. Therefore, I. viscosa may serve as a new therapeutic agent for wound healing.
Yazarlar (6)
1
Ahmet Harmankaya
ORCID: 0000-0001-9923-6723
2
Irfan Cinar
ORCID: 0000-0002-9826-2556
3
Muhammed Yayla
ORCID: 0000-0002-0659-3084
4
Sezen Harmankaya
ORCID: 0000-0003-2498-5003
5
Murat Beytur
ORCID: 0000-0002-7098-5592
6
Cem Öziç
ORCID: 0000-0001-5415-9277
Anahtar Kelimeler
cell proliferation
extraction
Medicinal plants
oxidative status
scratch assay
Kurumlar
Kafkas Üniversitesi
Kars Turkey
Kastamonu University
Kastamonu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fabad Journal of Pharmaceutical Sciences
Q3
SJR Skoru0,211
H-Index23
YayıncıSociety of Pharmaceutical Sciences of Ankara (FABAD)
ÜlkeTurkey
Pharmaceutical Science (Q3)
Metrikler
2
Atıf
6
Yazar
5
Anahtar Kelime