Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of gossypin on acetaminophen-induced hepatotoxicity in mice
Trakya University Journal of Natural Sciences · Nisan 2024
YÖKSİS Kayıtları
Effects of gossypin on acetaminophen-induced hepatotoxicity in mice
Trakya University Journal of Natural Sciences · 2024 ESCI
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiTrakya University Journal of Natural Sciences
Yayın TarihiNisan 2024
Cilt / Sayfa25 · 81-90
Scopus ID2-s2.0-85205483068
Erişim🔓 Açık Erişim
Özet
Liver injury from paracetamol (acetaminophen) (APAP) is common worldwide. To prevent intoxication with a drug with high poisoning, treatment can be made possible with an easily accessible and harmless substance. This study aimed to investigate the hepa-toprotective effects of Gossypin (GOS) in mice exposed to an overdose of APAP-the possible mechanism of action. Specifically, serum [alanine aminotransferase (ALT), aspartate transaminase (AST), and hepatic biochemical parameters (glutathione (GSH), malondial-dehyde (MDA) and superoxide dismutase (SOD)] were evaluated. Protein and mRNA levels of inflammatory, apoptotic, and cytochrome factors, including TNF-α, IL-1β, IL-6, NF-kB, and CYP2E1, were analyzed using real-time PCR. Pretreatment with GOS signifi-cantly reduced APAP-induced hepatic injury via oxidative stress. Along with potent anti-oxidant activity, GOS promoted APAP hepatic detoxification by regulating AST, ALT, GSH, MDA, and SOD activities and mRNA levels of the cytochrome CYP2E1 gene. The anti-inflammatory activity of GOS increases its production. TNF-α, IL-1β and IL-6, through possible NF-kB blockade, are also responsible for its hepatoprotective effect. Taken together, GOS has the potential to be developed as a preventive agent to be admin-istered to patients suffering from APAP overdose.
Yazarlar (4)
1
Irfan Cinar
ORCID: 0000-0002-9826-2556
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Erdem Toktay
ORCID: 0000-0002-0715-2707
4
Damla Binnetoğlu
ORCID: 0000-0002-7041-7253
Anahtar Kelimeler
Acetaminophen
Anti-oxidative
AST
CYP2E1
Gossypin
NF-kB
Kurumlar
Kafkas Üniversitesi
Kars Turkey
Kastamonu University
Kastamonu Turkey