Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Effects of gossypin on acetaminophen-induced hepatotoxicity in mice
Trakya University Journal of Natural Sciences · Nisan 2024
YÖKSİS Kayıtları
Effects of gossypin on acetaminophen-induced hepatotoxicity in mice
Trakya University Journal of Natural Sciences · 2024 ESCI
Dr. Öğr. Üyesi MUHAMMED YAYLA →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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2019 ISSN: 2147-0294 Emerging Sources Citation Index, TR Dizin
Prof. Dr. HASAN HÜSEYİN DOĞAN →
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2020 ISSN: 2147-0294 TR DİZİN
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2021 ISSN: 2147-0294 Emerging Sorches Sciences index
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THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY
2021 ISSN: 2147-0294 Emerging Sorches Sciences index
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A NEW TRUFFLE SPECIES ADDITION, TUBER MACROSPORUM, TO TURKISH MYCOTA
2021 ISSN: 2147-0294 Emerging Sorches Sciences index
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Biological activity evaluation of three Hypericum species wild growing in Sivas province of Turkey
2022 ISSN: 2147-0294 Web of Science - Emerging Sources Citation Index (ESCI)
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2024 ISSN: 2147-0294 ESCI
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
Makale Bilgileri
ISSN21470294
Yayın TarihiNisan 2024
Cilt / Sayfa25 · 81-90
Scopus ID2-s2.0-85205483068
Erişim🔓 Açık Erişim
Özet
Liver injury from paracetamol (acetaminophen) (APAP) is common worldwide. To prevent intoxication with a drug with high poisoning, treatment can be made possible with an easily accessible and harmless substance. This study aimed to investigate the hepa-toprotective effects of Gossypin (GOS) in mice exposed to an overdose of APAP-the possible mechanism of action. Specifically, serum [alanine aminotransferase (ALT), aspartate transaminase (AST), and hepatic biochemical parameters (glutathione (GSH), malondial-dehyde (MDA) and superoxide dismutase (SOD)] were evaluated. Protein and mRNA levels of inflammatory, apoptotic, and cytochrome factors, including TNF-α, IL-1β, IL-6, NF-kB, and CYP2E1, were analyzed using real-time PCR. Pretreatment with GOS signifi-cantly reduced APAP-induced hepatic injury via oxidative stress. Along with potent anti-oxidant activity, GOS promoted APAP hepatic detoxification by regulating AST, ALT, GSH, MDA, and SOD activities and mRNA levels of the cytochrome CYP2E1 gene. The anti-inflammatory activity of GOS increases its production. TNF-α, IL-1β and IL-6, through possible NF-kB blockade, are also responsible for its hepatoprotective effect. Taken together, GOS has the potential to be developed as a preventive agent to be admin-istered to patients suffering from APAP overdose.
Yazarlar (4)
1
Irfan Cinar
ORCID: 0000-0002-9826-2556
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Erdem Toktay
ORCID: 0000-0002-0715-2707
4
Damla Binnetoğlu
ORCID: 0000-0002-7041-7253
Anahtar Kelimeler
Acetaminophen
Anti-oxidative
AST
CYP2E1
Gossypin
NF-kB
Kurumlar
Kafkas Üniversitesi
Kars Turkey
Kastamonu University
Kastamonu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Trakya University Journal of Natural Sciences
Q4
OA
SJR Skoru0,225
H-Index7
ÜlkeTurkey
Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q4)
Molecular Biology (Q4)
Metrikler
3
Atıf
4
Yazar
6
Anahtar Kelime