Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Endoscopic endonasal transsphenoidal treatment for acromegaly: 2010 consensus criteria for remission and predictors of outcomes
Turkish Neurosurgery · Ocak 2014
YÖKSİS Kayıtları
Endoscopic endonasal transsphenoidal treatment for acromegaly: 2010 consensus criteria for remission and predictors of outcomes
Turkish Neurosurgery · 2014 SCI-Expanded
DOÇENT MERT ŞAHİNOĞLU →
Endoscopic endonasal transsphenoidal treatment for acromegaly 2010 consensus criteria for remission and predictors of outcomes
Turkish Neurosurgery · 2014 SCI-Expanded
DOÇENT MERT ŞAHİNOĞLU →
Makale Bilgileri
DergiTurkish Neurosurgery
Yayın TarihiOcak 2014
Cilt / Sayfa24 · 906-912
Scopus ID2-s2.0-84938937431
Erişim🔓 Açık Erişim
Özet
Aim: Acromegaly is a chronic disorder characterized by enhanced growth hormone (GH) secretion and elevated insulin-like growth factor-I (IGF-I) levels, usually caused by pituitary adenomas. In this retrospective study, we reviewed our experience with endoscopic endonasal transsphenoidal surgery (EETS) with in remission rates using the 2010 consensus criteria, predictors of remission and associated complications. Material and Methods: The authors retrospectively analyzed data from 56 acromegalic patients who underwent pure EETS. Tumors were classified according to size and suprasellar/parasellar extension. The criteria of remission were GH levels < 1 ng/mL randomly, < 0.4 ng/mL after oral glucose tolerance test and normal IGF-I levels for age and sex within the first 3 and 6 months after surgery. Results: Biochemical remission was achieved in 4 of 5 microadenomas (80%) and in 33 of 51 macroadenomas (64.7%). The total remission rate was 66.1% (37 of 56 adenomas). Age, gender and suprasellar extension did not affect the remission rate. However, cavernous sinus invasion, sphenoid sinus invasion and history of prior surgery were associated with lower rates of disease control. Conclusion: EETS represents an effective and safe option for the treatment of patients with acromegaly. High disease control rates and a small number of complications are some of the most important points related to the technique.
Yazarlar (8)
1
A. E. Yildirim
2
Mert Sahinoglu
ORCID: 0000-0003-0633-8304
3
Denizhan Divanlioglu
4
Fatih Alagöz
5
Ahmet Gurhan Gurcay
6
Ergun Daglioglu
7
Hilmi Onder Okay
8
A. D. Belen
Anahtar Kelimeler
Acromegaly
Endoscopic transsphenoidal surgery
Predictive factors
Remission
Kurumlar
Ankara Numune Education and Research Hospital
Ankara Turkey
Ataturk Training and Research Hospital
Izmir Turkey
Erzurum Education and Research Hospital
Erzurum Turkey
Metrikler
32
Atıf
8
Yazar
4
Anahtar Kelime