Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve
Ulusal Travma Ve Acil Cerrahi Dergisi · Ocak 2022
YÖKSİS Kayıtları
Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY · 2022 SCI
Doç. Dr. MERT ŞAHİNOĞLU →
Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve
Turkish Journal of Trauma and Emergency Surgery · 2020 SCI-Expanded
Doç. Dr. MERT ŞAHİNOĞLU →
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Epidemiologic Evaluation of Patients with Major Burns and Recommendations for Fighting with Burns
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Epidemiologic evaluation of patients with major burns and recommendations for burn prevention.
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2007 ISSN: 1306-696X SCI-Expanded 4 atıf
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Predictive value of preoperative neutrophil-to-lymphocyte ratio while detecting bowel resection in hernia with intestinal incarceration
2018 ISSN: 1306-696X SCI-Expanded
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The reconstruction of soft tissue defects in the elbow area: a treatment algorithm proposal
2009 ISSN: 1306-696X TR DİZİN
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Posterior Interosseous Flap versus Reverse Adipofascial Radial Forearm Flap For Soft Tissue reconstruction Of Dorsal Hand Defects
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The effect of nitroglycerin in the zone of stasis in a rat burn model
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The effects of nitroglycerin in the zone of stasis in a ratburn model
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High-pressure injection injuries to the upper extremity and the review of the literature
2020 ISSN: 1306-696X SCI-Expanded
Prof. Dr. ZEKERİYA TOSUN →
Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve
2020 ISSN: 1306-696X SCI-Expanded
Doç. Dr. MERT ŞAHİNOĞLU →
Role of ultrasound simulators in the training for Focused Assessment with Sonography for Trauma (FAST)
2021 ISSN: 1306-696X SCI Q4
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Role of ultrasound simulators in the training for Focused Assessment with Sonography for Trauma (FAST)
2021 ISSN: 1306-696X SCI-Expanded
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Evaluating incorrect management of transferred pediatric burn patients
2016 ISSN: 1306-696X SCI-Expanded Q4
Doç. Dr. FATMA ÖZCAN SIKI →
High-pressure injection injuries to the upper extremity and the review of the literature
2020 ISSN: 1306-696X SCI-Expanded Q4
Doç. Dr. GÖKÇE YILDIRAN →
Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve
2022 ISSN: 1306-696X SCI
Doç. Dr. MERT ŞAHİNOĞLU →
Makale Bilgileri
ISSN1306696X
Yayın TarihiOcak 2022
Cilt / Sayfa28 · 242-248
Scopus ID2-s2.0-85127480674
Erişim🔓 Açık Erişim
Özet
BACKGROUND: Galantamine is well-known for its neuroprotective effects and is currently used in the treatment of individuals with Alzheimer’s disease. In this study, we induced experimental sciatic nerve injury (SCI) in rats to test the beneficial effects of galantamine. METHODS: Thirty male Wistar albino rats were divided into three groups, as follows: sham, SCI + saline, and SCI + galantamine. After the administration of an intraperitoneal ketamine and xylazine mixture, which was used for anesthesia, SCI was induced by surgical clip compression at the midthigh region of the rats. After surgery, a single daily intraperitoneal dose of galantamine was adminis-tered for 7 days, and nerve tissue sections were obtained 1 week after injury. Histopathology studies were performed to assess neural thickness and apoptotic cell counts, and light microscopic morphological examination was used to determine a potential beneficial effect of galantamine on peripheral nerve degeneration. RESULTS: We observed a markedly increased microvasculature, increased nerve fiber thickness, and a statistically significant increase in apoptotic cell counts distal to the level of injury in the saline group compared with the sham group. However, the increases in nerve fiber thickness and apoptotic cell counts were less in the galantamine group compared with the saline group. CONCLUSION: In our experimental model, pharmacological intervention with galantamine demonstrated a protective effect on degeneration after peripheral nerve injury.
Yazarlar (7)
1
Fatih Alagöz
2
Mert Sahinoglu
ORCID: 0000-0003-0633-8304
3
D. Billur
4
Sevim Aydın
5
Rifat Akdağ
6
Durmuş Oğuz Karakoyun
7
Ergun Daglioglu
Anahtar Kelimeler
Infratrochlear sinir bloğu
orbital kompartman sendromu
perioküler anestezi, probing
retrobulbar hemoraji
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ordu Üniversitesi
Ordu Turkey
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Ulusal Travma ve Acil Cerrahi Dergisi
Q2
SJR Skoru0,377
H-Index33
YayıncıTurkish Association of Trauma and Emergency Surgery
ÜlkeTurkey
Emergency Medicine (Q2)
Anesthesiology and Pain Medicine (Q3)
Surgery (Q3)
Metrikler
1
Atıf
7
Yazar
4
Anahtar Kelime