Antiviral activity of Ribes uva-crispa L. extracts in vitro

Pakistan Journal of Pharmaceutical Sciences · Mayıs 2020

Makale Bilgileri

DergiPakistan Journal of Pharmaceutical Sciences

Yayın TarihiMayıs 2020

Cilt / Sayfa33 · 1173-1178

DOI10.36721/PJPS.2020.33.3.REG.1173-1178.1

Scopus ID2-s2.0-85090152655

Erişim🔓 Açık Erişim

Özet There is currently no approved vaccine or a useful antiviral drug against respiratory syncytial virus (RSV) that causes viral infection worldwide. Crude plant extracts can be an important resource for the development of new anti-RSV agents. In this study, cytotoxic and anti-RSV effect of the extracts Ribes uva-crispa, which has been known as "gooseberry" in Turkey and fruits used in the treatment of the various disorders, were evaluated by colorimetric XTT method. Results were expressed as 50% cytotoxicity (CC50), 50% effective concentration (EC50) and selectivity index (SI: CC50 / EC50). Of the tested extracts, the highest antiviral activity was found to be 96.90μg/mL EC50 and 11.70 SI from fruit aqueous extract; it was followed by leaf methanol extract (EC50: 2527.41μg/mL, SI: 6.55), leaf aqueous extract (EC50: 1093.37µg/mL, SI: 1.40) and fruit methanol extract (EC50: 11262.35µg/mL, SI: 0.56), respectively. As a result, we can say that these extracts, especially Ribes uva-crispa fruit aqueous and leaf methanol extracts, are worthy of further studies for the development of new and unique anti-RSV drugs.