Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Nutritional and pharmacological potentials of the medicinal mushroom Ganoderma adspersum (Schulz.) Donk
South African Journal of Botany · Mart 2024
YÖKSİS Kayıtları
NutritionalandpharmacologicalpotentialsofthemedicinalmushroomGanodermaadspersum(Schulz.)Donk
South African Journal of Botany · 2024 SCI-Expanded
PROFESÖR HASAN HÜSEYİN DOĞAN →
Makale Bilgileri
DergiSouth African Journal of Botany
Yayın TarihiMart 2024
Cilt / Sayfa166 · 360-374
Scopus ID2-s2.0-85183515108
Erişim🔓 Açık Erişim
Özet
In this study, the nuraceutical and the pharmacological properties of the crude extract of a wild mushroom, Ganoderma adspersum (Schulz.) Donk collected from Tunisia, were investigated. The antioxidant, antibacterial, antiviral (HSV-1) activities as well as antiproliferative potential against humain breast cancer (MCF-7) cells in vitro were studied. The fruiting body of Ganoderma revealed high protein and carbohydrates contents as well as a rich minerals composition and a low fat content. The crude extract exhibited a strong scavenging activity against ABTS+ radicals (IC50 = 9.75 μg/mL) and a powerful antibacterial activity against all tested Gram-positive bacteria. In this respect, the tested extract displayed an acceptable cytotoxicity limit towards normal Vero cells with a maximum non-toxic concentration value (MNTC) of 1.53 mg/mL as well as a proliferation ability which reached 108.19 % and 113.83 mg/mL at MNTC and 0.781 mg/mL concentrations, respectively. In addition, at concentration of 1.5 mg/mL, the extract exhibited an antiviral capacity against the Herpes Simplex Virus (HSV-1) with a potent selective index of 40 and a high percentage of protection of 84.7 % as well as a significant inhibition of MCF-7 cancer cells (16. 23 % ± 0.08). Our results corroborate the dietetic profile of G. adspersum as well as the medicinal potential of its crude extract, which could promote beneficial effects on human health. This is the first report on the antiviral HSV-1 and anticancer properties of a hydroalcholic extract of G. adspersum which highlights its potential as a natural source of bioactive components that can be isolated and tested in vivo.
Yazarlar (13)
1
Sana Hamrouni Zahmoul
2
Rim Ladhar Chaabouni
3
Ameny Srih
4
Hasan Huseyin Dogan
5
Elif Varıcıoğlu
ORCID: 0000-0003-2221-8353
6
Imed Sbissi
ORCID: 0000-0002-5703-5760
7
Ursula Kües
ORCID: 0000-0001-9180-4079
8
Lamjed Toumi
9
Ali Tlili
10
Gregorio Peron
ORCID: 0000-0002-6007-6184
11
Nacim Louhichi
12
Mohamed Trigui
13
Karama Zouari Bouassida
Anahtar Kelimeler
Antibacterial
Antioxidant
Anti-proliferative
Antiviral
Ganoderma adspersum
Hydro-alcoholic extract
Mushroom
Kurumlar
Centre de Biotechnologie de Sfax
Sfax Tunisia
Faculté des Sciences de Sfax
Sfax Tunisia
Georg-August-Universität Göttingen
Gottingen Germany
Institut Sylvo-Pastoral de Tabarka
Tabarka Tunisia
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Brescia
Brescia Italy
Université de Gabès
Gabes Tunisia
University of Sfax
Sfax Tunisia
Metrikler
6
Atıf
13
Yazar
7
Anahtar Kelime