Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Elevated urinary methylmalonic acid/creatinine ratio and serum sterol levels in patients with acute ischemic stroke
Revista Romana de Medicina de Laborator · Ocak 2018
YÖKSİS Kayıtları
Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke
Revista Romana de Medicina de Laborator · 2018 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke
Revista Romana de Medicina de Laborator · 2018 SCI-Expanded
DOÇENT AHMET HAKAN EKMEKCİ →
Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke
Revista Romana de Medicina de Laborator · 2018 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiRevista Romana de Medicina de Laborator
Yayın TarihiOcak 2018
Cilt / Sayfa26 · 51-58
Scopus ID2-s2.0-85040743054
Erişim🔓 Açık Erişim
Özet
Introduction: Sitosterolemia, defined as phytosterolemia, is a rare autosomal recessive disease characterized by elevated blood sterol levels. Our aim was to investigate serum plant sterols, methylmalonic acid, vitamin B12, oxidized-LDL and homocysteine levels in ischemic and hemorrhagic stroke patients and healthy subjects. Material and Methods: 50 healthy subjects (without a family history of coronary artery disease) and 89 patients hospitalized in the Selcuk University neurology clinic or intensive care unit with a diagnosis of stroke were included in this study. Serum plant sterols, homocysteine and methylmalonic acid, oxidized-LDL, total cholesterol, triglycerides, HDL-Cholesterol and vitamin B12 levels were analyzed by gas chromatography-mass spectrometry, liquid-chromatography tandem mass spectrometry, commercially available ELISA kit, spectrophotometry and chemiluminescence methods, respectively. Results: Urinary methylmalonic acid/creatinine ratio (p< 0.05), serum β-sitosterol levels and β-sitosterol/ cholesterol ratio were significantly higher (p <0.01) in patients compared to the control group. There was a significant positive correlation between the serum OxLDL- methylmalonic acid, serum homocysteine- urinary methylmalonic acid /creatinine ratio, serum methylmalonic acid - Urinary methylmalonic acid (p<0.05), serum homocysteine- urinary methylmalonic acid, urinary methylmalonic acid-methylmalonic acid/creatinine ratio, serum methylmalonic acid- methylmalonic acid/creatinine ratio, serum beta-sitosterol- beta-sitosterol /cholesterol, total cholesterol-HDL, total cholesterol-LDL (p <0.01) levels and negative correlation between vitamin B12- serum methylmalonic acid (p<0.05), cholesterol-stigmasterol/cholesterol, LDL- stigmasterol/cholesterol (p <0.01) levels in the patient group. Conclusion: Our findings presented that the serum sitosterol levels were significantly higher in stroke patients compared to controls.
Yazarlar (6)
1
Abdullah Sivrikaya
2
Şerefnur Öztürk
3
Ahmet Hakan Ekmekci
4
Aslıhan Sağlam
5
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
6
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Creatinine
Methylmalonic acid
Oxidized LDL
Sterol
Stroke
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
6
Yazar
5
Anahtar Kelime