Scopus
YÖKSİS Eşleşti
Elevated levels of neopterin and pentraxin 3 in patients with rheumatoid arthritis
Hormone Molecular Biology and Clinical Investigation · Aralık 2021
YÖKSİS Kayıtları
Elevated Levels of Neopterin and Pentraxin 3 in Patients with Rheumatoid Arthritis
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
PROFESÖR ABDULLAH SİVRİKAYA →
Elevated Levels of Neopterin and Pentraxin 3 in Patients with Rheumatoid Arthritis
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
PROFESÖR SEMA YILMAZ →
Makale Bilgileri
DergiHormone Molecular Biology and Clinical Investigation
Yayın TarihiAralık 2021
Cilt / Sayfa42 · 419-423
Scopus ID2-s2.0-85111595239
Özet
Objectives: As a systemic inflammatory disease, rheumatoid arthritis (RA) is the most common inflammatory arthritis in the population and there is no specific diagnostic marker in laboratory tests. The purpose of the study was to determine whether serum neopterin and pentraxin 3 (PTX3) levels may be a marker of increased inflammation in RA patients. Materials and methods: The study were consist of 30 RA patients and 30 healthy controls who were admitted to the department of rheumatology. Blood specimens were taken from both group, and the levels of neopterin were analyzed by chromatography method (HPLC) and the PTX 3 levels were measured by enzyme-linked immunosorbent assay (ELISA). All data and demographic characteristics of participants were also recorded. Results: Serum neopterin and PTX 3 levels of the patient group (25.99 ± 7.24 ng/mL and 4.19 ± 1.01 ng/dL, respectively) was higher than the control group (9.55 ± 0.74 ng/mL and 2.23 ± 0.39 ng/dL, respectively). These results were remarkable significant (p<0.01). No statistically significant correlation was found between age-PTX 3, age-neopterin and PTX 3-neopterin parameters in the patient group. In the control group, a significant negative correlation was found between age and PTX 3 (p<0.05), and a positive correlation between neopterin and PTX 3. Conclusions: Consequently, the serum neopterin and PTX 3 levels were higher in RA patients as compared to the healthy individuals. Our study suggest that there is a relation between neopterin and PTX 3 levels with RA patients. These findings suggest that neopterin and PTX 3 are important markers in the monitoring of RA disease.
Yazarlar (5)
1
Sabri Ekin
2
Abdullah Sivrikaya
3
Turan Akdağ
ORCID: 0000-0003-3175-6751
4
Sema Yılmaz
ORCID: 0000-0003-4277-3880
5
Semral Gülcemal
ORCID: 0000-0002-6085-9939
Anahtar Kelimeler
inflammation
neopterin
pentraxin 3
rheumatoid arthritis
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
5
Atıf
5
Yazar
4
Anahtar Kelime