Scopus
YÖKSİS Eşleşti
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
International Journal of Neuroscience · Ocak 2022
YÖKSİS Kayıtları
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
INTERNATIONAL JOURNAL OF NEUROSCIENCE · 2020 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
International Journal of Neuroscience · 2020 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
International Journal of Neuroscience · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
INTERNATIONAL JOURNAL OF NEUROSCIENCE · 2022 EBSCO, İndex Copernicus
PROFESÖR ALİ ÜNLÜ →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
INTERNATIONAL JOURNAL OF NEUROSCIENCE · 2022 Scopus
PROFESÖR ALİ ÜNLÜ →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
International Journal of Neuroscience · 2022 scopus
PROFESÖR ABDULLAH SİVRİKAYA →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
International Journal of Neuroscience · 2020 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
INTERNATIONAL JOURNAL OF NEUROSCIENCE · 2022 Scopus
PROFESÖR SEDAT ABUŞOĞLU →
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
International Journal of Neuroscience · 2020 SCI-Expanded
PROFESÖR SEDAT ABUŞOĞLU →
Makale Bilgileri
DergiInternational Journal of Neuroscience
Yayın TarihiOcak 2022
Cilt / Sayfa132 · 826-834
Scopus ID2-s2.0-85094907624
Özet
Aim: There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. Materials and Methods: A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Results: Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. Conclusions: These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.
Yazarlar (8)
1
Ayhan Bilgiç
ORCID: 0000-0003-0703-2630
2
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
3
Çağla Sadıç Çelikkol
4
Mehmet B. Oflaz
5
Ömer Faruk Akça
6
Abdullah Sivrikaya
7
Tamer Baysal
8
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Autism spectrum disorder
kynurenine
preschool children
toddlers
tryptophan
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
8
Yazar
5
Anahtar Kelime