Scopus
YÖKSİS DOI Eşleşti
SJR Q3
The protective effects of chitosan oligosaccharide (COS) on cadmium-induced neurotoxicity in Wistar rats
Archives of Environmental and Occupational Health · Ocak 2022
YÖKSİS Kayıtları
The protective effects of chitosan oligosaccharide (COS) on cadmium-induced neurotoxicity in Wistar rats
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH · 2021 SCI-Expanded
Prof. Dr. NURCAN DÖNMEZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
8 Hydroxydeoxyguanosine as a Useful Marker for Determining the Severity of Trichloroethylene Exposure
2014 ISSN: 1933-8244 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
Mycotoxin carry-over in breast milk and weight of infant in exclusively-breastfed infants
2021 ISSN: 1933-8244 SCI-Expanded Q4
Prof. Dr. SUZAN YALÇIN →
The protective effects of chitosan oligosaccharide (COS) on cadmium-induced neurotoxicity in Wistar rats
2021 ISSN: 1933-8244 SCI-Expanded Q2
Prof. Dr. NURCAN DÖNMEZ →
Makale Bilgileri
ISSN19338244
Yayın TarihiOcak 2022
Cilt / Sayfa77 · 755-763
Scopus ID2-s2.0-85120056485
Özet
The aim of the study was to investigate the influence of chitosan oligosaccharide (COS) on some antioxidant and cytokine levels in the rat hippocampus as well as synaptophysin (SYP) immunoreactivity in the cerebral cortex of the cadmium (Cd) exposed rats. Thirty-two male albino Wistar rats were divided randomly into four equal groups as control (C; n = 8), Cd (n = 8), COS (n = 8), and Cd + COS (CdCOS; n = 8). The rats in the Cd and CdCOS groups received Cd chloride (CdCl2) (2 mg/kg/d) orally by gastric gavage three times a week for 4 weeks. Besides, COS (200 mg/kg/d) was administered to COS and CdCOS groups five times a week for 4 weeks. Then, they were decapitated and hippocampal/cerebral cortex tissue samples were taken for measurement of GSH levels, CAT and SOD activities, MDA values, TNF-α, IL-6, and IL-10 levels as well as SYP immunoreactivity. Although tissue GSH levels were determined the lowest in the Cd group, these values were attenuated with COS treatment in the CdCOS group (p <.01). In addition, TNF-α levels were alleviated by COS treatment in the CdCOS group when compared to Cd (p <.01). SYP-positive cells were investigated in the cerebral cortex and found mild in the CdCOS group. COS exhibits potential protective effects on Cd-induced neurotoxicity in rats.
Yazarlar (5)
1
Ihsan Kisadere
ORCID: 0000-0003-0732-0464
2
M. Karaman
3
M. Faruk Aydin
4
Nurcan Dönmez
5
Mustafa Usta
Anahtar Kelimeler
Antioxidants
cadmium
chitosan oligosaccharide
cytokine
rat
Kurumlar
Balikesir Üniversitesi
Balikesir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Archives of Environmental and Occupational Health
Q3
SJR Skoru0,460
H-Index71
YayıncıTaylor and Francis Ltd.
ÜlkeUnited States
Environmental Science (miscellaneous) (Q3)
Health, Toxicology and Mutagenesis (Q3)
Public Health, Environmental and Occupational Health (Q3)
Toxicology (Q3)
Metrikler
8
Atıf
5
Yazar
5
Anahtar Kelime